Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




PET Scans Track Progressive Stages of Alzheimer’s Disease

By MedImaging International staff writers
Posted on 16 Mar 2016
A new study reveals how positron emission tomography (PET) scans of Tau deposition can help track the progressive stages of Alzheimer’s disease (AD) in the brains of aging cognitively normal adults.

Researchers at the University of California Berkeley (USA) and Lawrence Berkeley National Laboratory (LBL; Berkeley, CA, USA) conducted a study to examine Tau deposition and retention patterns in 53 adults. Of these, 5 were young adults (20–26), 33 were cognitively healthy adults (64–90), and 15 were patients aged 53–77 who had been diagnosed with dementia resulting from probable AD. Tau deposition was measured using the PET agent (18)F-AV-1451, in a method established by German researchers through post-mortem analysis of the brains of suspected AD patients.

The results confirmed that with advancing age, tau protein accumulates in the medial temporal lobe, which hosts the hippocampus and the memory center of the brain, and that higher levels of tau in the medial temporal lobe was associated with greater declines in episodic memory. PET detection of tau in other isocortical regions, such as the neocortex, required the presence of β-amyloid, and was associated with a decline in global cognitive function. The study also confirmed that the patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The study was published on March 2, 2016, in Neuron.

“Braak staging was developed through data obtained from autopsies, but our study is the first to show the staging in people who are not only alive, but who have no signs of cognitive impairment,” said lead author Prof. William Jagust, PhD, of UC Berkeley and LBL. “Amyloid may somehow facilitate the spread of tau, or tau may initiate the deposition of amyloid. All I can say is that when amyloid starts to show up, we start to see tau in other parts of the brain, and that is when real problems begin. We think that may be the beginning of symptomatic Alzheimer’s disease.”

Tau is a microtubule protein important in maintaining the structure of neurons. They are abundant in neurons of the central nervous system (CNS) and are less common elsewhere, but are also expressed at very low levels in astrocytes and oligodendrocytes. Pathologies such as AD and Parkinson's disease are associated with tau protein oligomers that have become misfolded and defective, and no longer stabilize microtubules properly.

β-amyloid are peptides that are the main component of the amyloid plaques found in the brains of AD patients. It is believed that certain misfolded oligomers can induce other β-amyloid molecules to also take the misfolded oligomeric form, in a process similar to that of the tau protein, leading to a chain reaction akin to a prion infection that is toxic to nerve cells. There is some evidence that misfolded β-amyloid can also induce tau to misfold.

Related Links:

University of California Berkeley
Lawrence Berkeley National Laboratory



Gold Member
Ultrasound System
FUTUS LE
Gold Member
Electrode Solution and Skin Prep
Signaspray
Digital X-Ray Detector Panel
Acuity G4
Silver Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to MedImaging.net and get access to news and events that shape the world of Radiology.
  • Free digital version edition of Medical Imaging International sent by email on regular basis
  • Free print version of Medical Imaging International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of Medical Imaging International in digital format
  • Free Medical Imaging International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Radcal

Channels

MRI

view channel
Image: PET/MRI can accurately classify prostate cancer patients (Photo courtesy of 123RF)

PET/MRI Improves Diagnostic Accuracy for Prostate Cancer Patients

The Prostate Imaging Reporting and Data System (PI-RADS) is a five-point scale to assess potential prostate cancer in MR images. PI-RADS category 3 which offers an unclear suggestion of clinically significant... Read more

General/Advanced Imaging

view channel
Image: The Tyche machine-learning model could help capture crucial information. (Photo courtesy of 123RF)

New AI Method Captures Uncertainty in Medical Images

In the field of biomedicine, segmentation is the process of annotating pixels from an important structure in medical images, such as organs or cells. Artificial Intelligence (AI) models are utilized to... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.
167 queries executed
1
(!!!!! 2063.9896392822): SET sql_mode = 'MYSQL40'
2 (625.1335144043): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering
3 (458.95576477051): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294763256 ) ORDER BY menuid DESC LIMIT 1
4 (613.92784118652): DELETE FROM jos_session WHERE time < 1745962717 AND guest = 1 AND userid = 0
5 (43.153762817383): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
6 (331.87866210938): SELECT * FROM jos_session WHERE session_id = '19fae43e0c137151323a10bd5bb12d3e'
7 (321.86508178711): UPDATE jos_session SET `time`='1745963617',`userid`='0',`usertype`='\'\'',`username`='',`gid`='0',`guest`='1' WHERE session_id='19fae43e0c137151323a10bd5bb12d3e'
8 (!!!!! 14458.894729614): SELECT * FROM jos_menu WHERE id = 294763256
9 (!!!!! 1064.0621185303): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
10 (!!!!! 1301.0501861572): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
11 (82.015991210938): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
12 (!!!!! 1140.1176452637): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294763256) AND (fid=213) ORDER BY id DESC, `created` DESC LIMIT 0,16
13 (523.80561828613): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294763256) AND (fid=213) ORDER BY id DESC, `created` DESC LIMIT 0,16
14 (!!!!! 9006.9770812988): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=213 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294763256 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
15 (!!!!! 18645.048141479): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=213 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294763256 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
16 (!!!!! 4997.0149993896): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294763256 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
17 (!!!!! 2636.9094848633): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294763256 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
18 (!!!!! 3537.1780395508): SELECT name,id,title FROM jos_deeppockets WHERE id=213 LIMIT 1
19 (45.061111450195): SELECT name,id,title FROM jos_deeppockets WHERE id=213 LIMIT 1
20 (735.99815368652): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
21 (!!!!! 2586.1263275146): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
22 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
23 (!!!!! 1296.0433959961): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
24 (676.15509033203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
25 (319.9577331543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
26 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
27 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
28 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
29 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
30 (867.12837219238): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id
31 (155.92575073242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294763256 LIMIT 1
32 (35.762786865234): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294763256 LIMIT 1
33 (182.8670501709): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294763256 LIMIT 1
34 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294763256 LIMIT 1
35 (!!!!! 3069.1623687744): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1
36 (!!!!! 4207.1342468262): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1
37 (!!!!! 5944.0135955811): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294763256 ) ORDER BY ordering
38 (!!!!! 1335.8592987061): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
39 (161.88621520996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
40 (!!!!! 6411.075592041): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294763256 LIMIT 1
41 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294763256 LIMIT 1
42 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294763256 LIMIT 1
43 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294763256 LIMIT 1
44 (!!!!! 1621.0079193115): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294763256 LIMIT 1
45 (703.09638977051): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294763256 LIMIT 1
46 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294763256 LIMIT 1
47 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294763256 LIMIT 1
48 (222.20611572266): select journal.name,journal.id,dpcat.livesite,journal.code from jos_dp_categories dpcat join jos_journal journal on journal.id=dpcat.journalid where dpcat.id=10
49 (!!!!! 1942.1577453613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
50 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
51 (!!!!! 1541.1376953125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
52 (!!!!! 3730.0586700439): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
53 (!!!!! 4544.9733734131): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
54 (!!!!! 2460.9565734863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
55 (!!!!! 7439.8517608643): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
56 (!!!!! 4528.0456542969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
57 (383.85391235352): SELECT name FROM jos_deeppockets WHERE id=294763256 LIMIT 1
58 (!!!!! 1292.9439544678): SELECT name FROM jos_deeppockets_archive WHERE id=294763256 LIMIT 1
59 (315.90461730957): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'
60 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
61 (!!!!! 2295.970916748): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
62 (!!!!! 3690.9580230713): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
63 (556.94580078125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
64 (!!!!! 2319.0975189209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
65 (155.92575073242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
66 (559.09156799316): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1
67 (535.96496582031): SELECT fid FROM jos_deeppockets WHERE id=294763256 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294763256 AND published='1' LIMIT 1
68 (290.87066650391): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`
69 (656.8431854248): select jos_twitters.link from jos_twitters where cat=10
70 (185.96649169922): select jos_facebook.link from jos_facebook where cat=10
71 (38.14697265625): select jos_google_plus.link from jos_google_plus where cat=10
72 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10
73 (798.94065856934): SELECT fid FROM jos_deeppockets WHERE id=294763256 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294763256 AND published='1' LIMIT 1
74 (59.127807617188): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`
75 (781.05926513672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
76 (313.04359436035): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
77 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
78 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1
79 (83.92333984375): SELECT show_live FROM jos_com_show_setting LIMIT 1
80 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
81 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
84 (87.976455688477): SELECT show_live FROM jos_com_show_setting LIMIT 1
85 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
88 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
89 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
90 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
93 (27.894973754883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
94 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
95 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
105 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
106 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
107 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1
108 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
109 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
110 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
111 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
113 (175.95291137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
114 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
115 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
116 (401.97372436523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
117 (535.96496582031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
118 (364.06517028809): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
119 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
120 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
121 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
122 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
123 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
124 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
125 (308.03680419922): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
126 (!!!!! 49483.060836792): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
127 (237.94174194336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
128 (172.13821411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
129 (!!!!! 1482.0098876953): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763256 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763256 AND type='deeppockets_item' AND published='1' LIMIT 1
130 (!!!!! 682118.89266968): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
131 (!!!!! 6511.2113952637): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
132 (!!!!! 2236.1278533936): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
133 (169.99244689941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
134 (520.94459533691): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
135 (147.10426330566): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
136 (!!!!! 1710.8917236328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
137 (655.8895111084): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
138 (650.88272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
139 (426.05400085449): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
140 (344.03800964355): SELECT name FROM jos_deeppockets WHERE id=213
141 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=213
142 (982.04612731934): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
143 (417.94776916504): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
144 (423.19297790527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
145 (308.03680419922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
146 (!!!!! 11669.874191284): TRUNCATE TABLE jos_trademed_module
147 (169.99244689941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
148 (297.06954956055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
149 (!!!!! 1558.0654144287): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
150 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
151 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
152 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
153 (!!!!! 1748.0850219727): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
154 (160.93254089355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
155 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
156 (!!!!! 4957.914352417): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763256 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763256 AND type='deeppockets_item' AND published='1' LIMIT 1
157 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
158 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
159 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
160 (169.99244689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
161 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763256 AND published='1' LIMIT 1
162 (153.0647277832): select jos_twitters.link from jos_twitters where cat=10
163 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10
164 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10
165 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10
166 (305.8910369873): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
167 (!!!!! 3205.0609588623): insert into jos_banners_delta values (14615,'2025-04-29 21:53:40','3.148.202.74','view'),(14202,'2025-04-29 21:53:40','3.148.202.74','view'),(14203,'2025-04-29 21:53:40','3.148.202.74','view')