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Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

By MedImaging International staff writers
Posted on 16 May 2021

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An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology.

In the new study, researchers at the Radboud University Medical Center (Nijmegen, The Netherlands) developed an algorithm for lung nodule assessment using deep learning, an AI application capable of finding certain patterns in imaging data. The researchers trained the algorithm on CT images of more than 16,000 nodules, including 1,249 malignancies, from the National Lung Screening Trial. They validated the algorithm on three large sets of imaging data of nodules from the Danish Lung Cancer Screening Trial.

The deep learning algorithm delivered excellent results, outperforming the established Pan-Canadian Early Detection of Lung Cancer model for lung nodule malignancy risk estimation. It performed comparably to 11 clinicians, including four thoracic radiologists, five radiology residents and two pulmonologists. The researchers plan to continue improving the algorithm by incorporating clinical parameters like age, sex and smoking history. They are also working on a deep learning algorithm that takes multiple CT examinations as input. The current algorithm is highly suitable for analyzing nodules at the initial, or baseline, screening, but for nodules detected at subsequent screenings, growth and appearance in comparison to the previous CT are important. The researchers have developed other algorithms to reliably extract imaging features from the chest CT related to chronic obstructive pulmonary diseases and cardiovascular diseases. They will be investigating how to effectively integrate these imaging features into the current algorithm.

“The algorithm may aid radiologists in accurately estimating the malignancy risk of pulmonary nodules,” said the study’s first author, Kiran Vaidhya Venkadesh, a Ph.D. candidate with the Diagnostic Image Analysis Group at Radboud University Medical Center in Nijmegen, the Netherlands. “This may help in optimizing follow-up recommendations for lung cancer screening participants.”

“As it does not require manual interpretation of nodule imaging characteristics, the proposed algorithm may reduce the substantial interobserver variability in CT interpretation,” said senior author Colin Jacobs, Ph.D., assistant professor in the Department of Medical Imaging at Radboud University Medical Center in Nijmegen. “This may lead to fewer unnecessary diagnostic interventions, lower radiologists’ workload and reduce costs of lung cancer screening.”

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91 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

92 (108.95729064941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294788234 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

94 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

95 (286.10229492188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294788234 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (512.83836364746): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (310.18257141113): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

99 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

100 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

101 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

102 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

103 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

104 (288.96331787109): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

105 (!!!!! 90200.901031494): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

106 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

107 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

108 (!!!!! 2704.8587799072): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294788234 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294788234 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 1267491.1022186): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (!!!!! 1894116.8785095): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (!!!!! 3558.874130249): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

112 (290.1554107666): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (!!!!! 1126.0509490967): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

114 (!!!!! 1336.0977172852): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (!!!!! 1070.9762573242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

116 (48.87580871582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (!!!!! 3572.940826416): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

118 (!!!!! 3095.1499938965): SELECT name FROM jos_deeppockets WHERE id=216

119 (842.09442138672): SELECT name FROM jos_deeppockets WHERE id=216

120 (!!!!! 1929.0447235107): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

121 (!!!!! 2315.0444030762): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (!!!!! 7169.9619293213): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

123 (488.9965057373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

124 (!!!!! 32416.105270386): TRUNCATE TABLE jos_trademed_module

125 (777.9598236084): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294788234 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

126 (!!!!! 1344.9192047119): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

127 (!!!!! 3187.894821167): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (!!!!! 1245.9754943848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

129 (!!!!! 1097.9175567627): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

130 (!!!!! 15210.151672363): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

131 (!!!!! 3751.9931793213): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

132 (!!!!! 1594.7818756104): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

133 (!!!!! 4497.0512390137): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294788234 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294788234 AND type='deeppockets_item' AND published='1' LIMIT 1

134 (!!!!! 4864.9311065674): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

135 (!!!!! 2449.9893188477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

136 (45.061111450195): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

137 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

138 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294788234 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294788234 AND published='1' LIMIT 1

139 (!!!!! 6417.989730835): select jos_twitters.link from jos_twitters where cat=10

140 (!!!!! 9244.2035675049): select jos_facebook.link from jos_facebook where cat=10

141 (!!!!! 7926.9409179688): select jos_google_plus.link from jos_google_plus where cat=10

142 (!!!!! 7943.868637085): select jos_linkedin.link from jos_linkedin where cat=10

143 (!!!!! 3633.975982666): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

144 (!!!!! 2545.8335876465): insert into jos_banners_delta values (14615,'2025-04-29 10:23:38','3.148.162.188','view'),(14202,'2025-04-29 10:23:38','3.148.162.188','view'),(14203,'2025-04-29 10:23:38','3.148.162.188','view')

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