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3D Mammography Almost Halves Breast Cancer Incidence between Two Screening Tests

By MedImaging International staff writers
Posted on 29 Mar 2024
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Image: 3D mammography almost halves the incidence of breast cancer between two screening tests (Photo courtesy of University of Cordoba)
Image: 3D mammography almost halves the incidence of breast cancer between two screening tests (Photo courtesy of University of Cordoba)

Breast cancer represents 28.9% of all cancers in women and is the primary cause of cancer-related deaths among this group. Interval breast cancers are those diagnosed in the period between two screening sessions, following a screening test that yielded a negative result, and before the next scheduled screening. This occurrence serves as a crucial measure of the efficiency of breast cancer early detection programs: a high frequency of cancers detected between screenings suggests the program's ineffectiveness, whereas a low frequency indicates its success in identifying the disease at an early stage. Now, a clinical study has revealed the effectiveness of breast tomosynthesis in reducing the incidence of interval carcinomas, thereby recommending its integration into breast cancer early detection strategies.

A clinical trial led by the University of Cordoba (Córdoba, Spain) that involved close to 40,000 revealed the effectiveness of breast tomosynthesis in almost halving the incidence of this type of cancer that appears between two rounds of screening. This method, which is an advancement over traditional 2D mammography, utilizes X-rays to generate a 3D image of the breast, reducing the obscuration of lesions caused by overlapping tissues when recreating a volumetric image. Also known as 3D mammography it is widely adopted in diagnostic settings, although its integration into screening programs remains limited.

Over a two-year period, the research compared traditional 2D mammography screening with a combined approach including tomosynthesis in a regional screening program. Of nearly 24,000 women screened using only 2D mammograms, the interval cancer rate stood at 1.8 per thousand, while the rate dropped to 0.93 per thousand among the 16,000 women also screened with tomosynthesis, marking a 49% decrease in interval cancer likelihood with the 3D method. This reduction was particularly pronounced in women with dense breast tissue, where the detection of lesions is notoriously more challenging.

Further, the study revealed that interval cancers identified through tomosynthesis were generally smaller than those detected via digital mammography alone, which is positive given the correlation between tumor size and prognosis. This indicates tomosynthesis' superior diagnostic capabilities might be responsible for the reduced size of undetected tumors. The findings advocate for the systematic incorporation of breast tomosynthesis into population-based breast cancer early detection programs, given its potential to enhance the efficacy of these initiatives.

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97 (298.97689819336): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
98 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
99 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
100 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
101 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
102 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
103 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
104 (183.10546875): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
105 (!!!!! 123795.98617554): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
106 (!!!!! 11368.036270142): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
107 (!!!!! 7437.9444122314): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
108 (!!!!! 7755.0411224365): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800712 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800712 AND type='deeppockets_item' AND published='1' LIMIT 1
109 (!!!!! 1361850.0232697): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
110 (87.976455688477): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
111 (!!!!! 1449.8233795166): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
112 (74.148178100586): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
113 (!!!!! 1745.2239990234): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
114 (78.916549682617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
115 (279.18815612793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
116 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
117 (268.93615722656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
118 (160.21728515625): SELECT name FROM jos_deeppockets WHERE id=211
119 (143.05114746094): SELECT name FROM jos_deeppockets WHERE id=211
120 (488.9965057373): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
121 (410.07995605469): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
122 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
123 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
124 (!!!!! 8679.1515350342): TRUNCATE TABLE jos_trademed_module
125 (720.02410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800712 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
126 (509.02366638184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
127 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
128 (!!!!! 2263.069152832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
129 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
130 (!!!!! 1230.9551239014): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
131 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
132 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
133 (146.15058898926): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800712 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800712 AND type='deeppockets_item' AND published='1' LIMIT 1
134 (62.942504882812): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
135 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)
136 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
137 (!!!!! 2820.9686279297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
138 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800712 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800712 AND published='1' LIMIT 1
139 (66.995620727539): select jos_twitters.link from jos_twitters where cat=10
140 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10
141 (27.894973754883): select jos_google_plus.link from jos_google_plus where cat=10
142 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10
143 (302.79159545898): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
144 (975.13198852539): insert into jos_banners_delta values (14615,'2025-04-29 10:54:53','3.23.60.252','view'),(14202,'2025-04-29 10:54:53','3.23.60.252','view'),(14203,'2025-04-29 10:54:53','3.23.60.252','view')