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Novel PET Imaging Tracer Noninvasively Identifies Cancer Gene Mutation for More Precise Diagnosis

By MedImaging International staff writers
Posted on 21 Dec 2023

Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene that is found in about 20-70% of cancer cases. Patients with KRAS mutations generally respond poorly to standard therapies. Hence, it is recommended to assess the mutation status in cancer patients to determine the most effective treatment. Presently, screening for KRAS mutation involves a biopsy combined with gene sequencing. However, biopsies can be accompanied by significant complications and have limited use owing to the quality of the tissue sample. This creates an urgent need for accurate yet noninvasive methods for the evaluation of the KRAS mutation status. Now, a study has found a novel PET imaging tracer to safely and effectively detect the common KRAS cancer gene mutation that is an important molecular marker for tumor-targeted therapy. Early identification of this can allow physicians to tailor treatment plans for patients to achieve the best results.

Researchers at Fourth Military Medical University (Xi’an, China) conducted this first-in-human study to develop a KRAS-targeted radiotracer and examine its targeting potential in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). The researchers created an oncoprotein-targeted PET tracer, 18F-PFPMD, based on a recently FDA-approved KRASG12C inhibitor. The team conducted both in vitro and in vivo studies to assess the tracer’s targeting specificity and imaging ability. The researchers also carried out further evaluation in healthy volunteers, NSCLC patients, and CRC patients.

The researchers obtained 18F-PFPMD with a high radiochemical yield, radiochemical purity, and stability and proved that it could selectively bind to the KRASG12C protein in preclinical studies. They found the tracer to be safe for humans, with the ability to clear rapidly from the gallbladder and intestines. Among NSCLC and CRC patients, the accumulation of 18F-PFPMD was much higher in tumors with the KRASG12C mutation as compared to those without the mutation.

“This research reveals that 18F-PFPMD is a promising molecular imaging tool of significant clinical relevance,” said Jing Wang, MD, PhD, nuclear medicine physician at Xijing Hospital of Fourth Military Medical University. “Moving forward, the tracer could be useful to screen the KRASG12C mutation status, as well as for patient selection of KRASG12C targeted therapy. Moreover, it could be used for monitoring therapeutic response and drug resistance for cancer patients.”

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86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

92 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

93 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799676 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

95 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

96 (380.03921508789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799676 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (674.00932312012): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (379.08554077148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

100 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

101 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

102 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

103 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

104 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

105 (315.90461730957): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

106 (!!!!! 22908.926010132): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

107 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

108 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

109 (427.9613494873): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799676 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799676 AND type='deeppockets_item' AND published='1' LIMIT 1

110 (!!!!! 608199.83482361): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (157.83309936523): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (385.04600524902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (138.0443572998): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (309.94415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (102.04315185547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (254.15420532227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (77.962875366211): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (350.9521484375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

119 (144.95849609375): SELECT name FROM jos_deeppockets WHERE id=213

120 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=213

121 (660.89630126953): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (516.89147949219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

124 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

125 (!!!!! 10607.957839966): TRUNCATE TABLE jos_trademed_module

126 (112.05673217773): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799676 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

127 (661.84997558594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

130 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

131 (!!!!! 1425.9815216064): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

132 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

133 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

134 (53.882598876953): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799676 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799676 AND type='deeppockets_item' AND published='1' LIMIT 1

135 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

136 (39.100646972656): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (54.121017456055): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

138 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

139 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799676 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799676 AND published='1' LIMIT 1

140 (143.05114746094): select jos_twitters.link from jos_twitters where cat=10

141 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

142 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

143 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

144 (370.97930908203): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

145 (!!!!! 1234.0545654297): insert into jos_banners_delta values (14615,'2025-04-29 16:16:38','3.17.61.107','view'),(14202,'2025-04-29 16:16:38','3.17.61.107','view'),(14203,'2025-04-29 16:16:38','3.17.61.107','view')

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