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Targeted Therapy Delivers Radiation Directly To Cells in Hard-To-Treat Cancers

By MedImaging International staff writers
Posted on 08 Jan 2024

Image: Researchers will study targeted radiation for treatment-resistant cancers (Photo courtesy of 123RF)

Alpha-particle emitter radiopharmaceutical therapy (alpha-emitter RPT) is an emerging cancer treatment that has shown considerable success in targeting widespread, resistant cancer cells by directly delivering potent radiation. Administered intravenously, this therapy involves attaching radioactive atoms, which emit alpha-particles or helium nuclei, to molecules specifically designed to bind with cancer cells scattered throughout the body. This targeted approach allows the alpha-particles to inflict substantial DNA damage to the cancer cells, effectively destroying them, while also minimizing harm to the surrounding healthy tissues and mitigating some of the severe side effects typically associated with radiation and chemotherapy.

In recent years, the FDA has approved several agents utilizing this method to deliver radiation therapies aimed at treatment-resistant cancers, sparking an increased demand to refine these treatments and explore new specific radiation therapies. Researchers at Johns Hopkins Medicine (Baltimore, MD, USA) who have previously established the efficacy of this therapy in managing various metastatic cancers that are unresponsive to standard treatments, are now set to further enhance the alpha-emitter RPT with a USD 15 million grant from the National Cancer Institute. Their focus will be on fine-tuning the therapy and customizing its use, including developing sophisticated imaging techniques and understanding the radiation's distribution in tissues to personalize treatment for each patient. The research team plans to delve into the mathematical and physics-based aspects of alpha-emitter RPT to address these challenges effectively.

“The study of these types of radiation treatments is a very active field that is also very niche,” said George Sgouros, Ph.D., director of the radiological physics division and professor of radiology and radiological science at the Johns Hopkins University School of Medicine. “It is a unique area of study because a multidisciplinary team is needed to fully optimize such therapies, everything from physics, radiochemistry, biology and pharmacokinetics impacts this treatment approach.”

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92 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799842 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

94 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

95 (370.02563476562): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799842 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (519.0372467041): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (411.9873046875): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

99 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

100 (140.90538024902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

101 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

102 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

103 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

104 (157.11784362793): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

105 (!!!!! 24426.937103271): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

106 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

107 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

108 (495.19538879395): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799842 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799842 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 459185.1234436): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (89.883804321289): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (240.80276489258): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

112 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (196.93374633789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

114 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (117.06352233887): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

116 (54.836273193359): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (311.85150146484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

118 (118.01719665527): SELECT name FROM jos_deeppockets WHERE id=213

119 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=213

120 (562.90626525879): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

121 (457.0484161377): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

123 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

124 (!!!!! 8810.9970092773): TRUNCATE TABLE jos_trademed_module

125 (112.05673217773): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799842 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

126 (832.79609680176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

127 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

129 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

130 (!!!!! 1609.0869903564): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

131 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

132 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

133 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799842 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799842 AND type='deeppockets_item' AND published='1' LIMIT 1

134 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

135 (27.179718017578): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

136 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

137 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

138 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799842 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799842 AND published='1' LIMIT 1

139 (108.00361633301): select jos_twitters.link from jos_twitters where cat=10

140 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

141 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

142 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

143 (327.11029052734): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

144 (!!!!! 1148.9391326904): insert into jos_banners_delta values (14615,'2025-04-29 16:36:31','3.144.13.165','view'),(14202,'2025-04-29 16:36:31','3.144.13.165','view'),(14203,'2025-04-29 16:36:31','3.144.13.165','view')

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