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Two-Part MRI Scan Detects Prostate Cancer More Quickly without Compromising Diagnostic Quality

By MedImaging International staff writers
Posted on 16 Apr 2024

Image: Shorter scan to diagnose prostate cancer can increase availability and reduce cost (Photo courtesy of 123RF)

Prostate cancer ranks as the most prevalent cancer among men. Over the last decade, the introduction of MRI scans has significantly transformed the diagnosis process, marking the most substantial advancement in 30 years. Currently, a standard 'multiparametric' MRI for those suspected of prostate cancer includes a three-part process, with the third part involving a dye injection. This MRI technique highlights any abnormalities that permit precisely targeted tissue biopsies, enhancing cancer detection. Fortunately, about one-third of these MRI results come back normal, providing reassurance to many and allowing them to avoid unnecessary biopsies. However, as the demand for prostate MRIs grows, the majority of men in need of these scans are unable to access them. Now, a new study has found that eliminating the dye injection step from the three-part MRI scan could make the scanning process faster and more cost-effective without compromising on diagnostic accuracy, thereby making the imaging technology more accessible.

The findings from a clinical trial led by University College London (London, UK) support the use of a two-part MRI scan for diagnosing prostate cancer, potentially leading to changes in clinical protocols. This study, known as PRIME, involved cancer specialists from 22 hospitals across 12 countries and recruited 555 patients to evaluate whether a shorter, 'biparametric' MRI without the dye injection could match the cancer detection rates of the traditional three-part MRI scan. Participants initially received the complete three-part multiparametric scan. Radiologists then evaluated the simpler two-part biparametric scan without the dye, as well as the three-part scan with the dye, for each patient. Targeted prostate biopsies were conducted as needed to verify diagnoses.

The results confirmed that the shorter two-part biparametric scan diagnosed important prostate cancer in 29% of patients, which was similar to the detection rate of the longer three-part multiparametric scan. Eliminating the contrast dye stage can reduce the scanning time by approximately one-third, which could enable more widespread use of MRI technology with the existing resources of scanners and operators. Moreover, a two-stage MRI not only saves time but also reduces costs, as it is 47% cheaper than the three-stage scan.

“The results of the trial indicate that in most patients we are unlikely to miss significant prostate cancer if we stop doing the contrast scan,” said Dr. Clare Allen, a lead radiologist on the trial from UCLH. “The scans will be quicker, cheaper and can be offered to more men. It is critical to emphasize that dropping the third part of the MRI scan is dependent on the first two parts of the scan being of high quality. MRI scanners in this study were optimized before they were used, so we would advise centers wishing to change to the two-part scan to ensure MRI scanners and image quality are optimized first.”

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90 (!!!!! 3427.9823303223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

91 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

92 (530.00450134277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800887 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (!!!!! 3309.0114593506): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

94 (!!!!! 2152.9197692871): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

95 (735.04447937012): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800887 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (930.0708770752): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (936.98501586914): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (!!!!! 2646.9230651855): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

99 (233.17337036133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

100 (!!!!! 3144.0258026123): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

101 (629.18663024902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

102 (!!!!! 2993.106842041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

103 (612.97416687012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

104 (809.90791320801): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

105 (!!!!! 56869.029998779): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

106 (974.89356994629): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

107 (91.791152954102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

108 (!!!!! 3831.8634033203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800887 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800887 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 1415828.9432526): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (288.00964355469): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (!!!!! 1190.185546875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

112 (297.78480529785): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (!!!!! 1334.9056243896): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

114 (91.075897216797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (!!!!! 1029.9682617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

116 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (396.0132598877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

118 (!!!!! 1482.0098876953): SELECT name FROM jos_deeppockets WHERE id=212

119 (141.14379882812): SELECT name FROM jos_deeppockets WHERE id=212

120 (501.87110900879): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

121 (!!!!! 1604.0802001953): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (!!!!! 3913.1641387939): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

123 (226.97448730469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

124 (!!!!! 4852.0565032959): TRUNCATE TABLE jos_trademed_module

125 (865.93627929688): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800887 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

126 (449.89585876465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

127 (91.791152954102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (811.10000610352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

129 (!!!!! 3435.8501434326): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

130 (!!!!! 1123.9051818848): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

131 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

132 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

133 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800887 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800887 AND type='deeppockets_item' AND published='1' LIMIT 1

134 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

135 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

136 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

137 (211.00044250488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

138 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800887 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800887 AND published='1' LIMIT 1

139 (!!!!! 9635.9252929688): select jos_twitters.link from jos_twitters where cat=10

140 (!!!!! 7973.9093780518): select jos_facebook.link from jos_facebook where cat=10

141 (!!!!! 7917.8810119629): select jos_google_plus.link from jos_google_plus where cat=10

142 (!!!!! 2328.1574249268): select jos_linkedin.link from jos_linkedin where cat=10

143 (462.05520629883): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

144 (!!!!! 1060.962677002): insert into jos_banners_delta values (14615,'2025-04-29 10:17:14','52.14.154.79','view'),(14202,'2025-04-29 10:17:14','52.14.154.79','view'),(14203,'2025-04-29 10:17:14','52.14.154.79','view')

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