Download Mobile App

Video Library

New PET Tracer Noninvasively Identifies Cancer Gene Mutation for More Precise Diagnosis

By MedImaging International staff writers
Posted on 03 Jan 2024

Kirsten rat sarcoma (KRAS) is a mutated oncogene that is commonly found in about 20-70% of all cancer cases, often leading to a poor response to standard therapies. Consequently, evaluating KRAS mutation status is critical in customizing the most effective therapy for cancer patients. Current methods for detecting KRAS mutations typically involve a biopsy followed by gene sequencing. However, biopsies carry risks of complications, and the accuracy is sometimes compromised due to tissue sample quality. Hence, there's a pressing demand for noninvasive yet precise ways to assess KRAS mutation status. Now, a novel PET imaging tracer has been proven to safely and effectively detect KRAS for targeted tumor therapy. Early identification of this mutation will allow healthcare professionals to design more effective, personalized treatment strategies.

In this first-in-human study, researchers at Xijing Hospital of Fourth Military Medical University (Xi’an, China) aimed to develop a KRAS-targeted radiotracer and explore its potential in targeting non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). The researchers developed an 18F-PFPMD tracer, based on a KRASG12C inhibitor recently approved by the FDA. They tested its targeting specificity and imaging ability through a series of in vitro and in vivo experiments, as well as further assessments involving healthy volunteers and patients with NSCLC and CRC.

The 18F-PFPMD tracer was obtained with high radiochemical yield, purity, and stability, and demonstrated a selective binding affinity for the KRASG12C protein in preclinical trials. It was also deemed safe for human use, demonstrating quick clearance through the gallbladder and intestines. Notably, in patients with NSCLC and CRC, the tracer accumulated significantly more in tumors harboring the KRASG12C mutation compared to those without, showcasing its potential as a diagnostic tool.

“This research reveals that 18F-PFPMD is a promising molecular imaging tool of significant clinical relevance,” said Jing Wang, MD, PhD, nuclear medicine physician at Xijing Hospital of Fourth Military Medical University. “Moving forward, the tracer could be useful to screen the KRASG12C mutation status, as well as for patient selection of KRASG12C targeted therapy. Moreover, it could be used for monitoring therapeutic response and drug resistance for cancer patients.”

Related Links:
Fourth Military Medical University

Visit expo >

Gold Member

Electrode Solution and Skin Prep

Signaspray

Gold Member

Ultrasound System

FUTUS LE

Ultrasonic Diagnostic System

K10

Ultrasound System

Acclarix AX2

Read the full article by registering today, it's FREE!

Free digital version edition of Medical Imaging International sent by email on regular basis
Free print version of Medical Imaging International magazine (available only outside USA and Canada).
Free and unlimited access to back issues of Medical Imaging International in digital format
Free Medical Imaging International Newsletter sent every week containing the latest news
Free breaking news sent via email
Free access to Events Calendar
Free access to LinkXpress new product services
REGISTRATION IS FREE AND EASY!

Sign in: Registered website members

Sign in: Registered magazine subscribers

Latest Nuclear Medicine News

Channels

Radiography

view channel

3D Mammography Almost Halves Breast Cancer Incidence between Two Screening Tests

Breast cancer represents 28.9% of all cancers in women and is the primary cause of cancer-related deaths among this group. Interval breast cancers are those diagnosed in the period between two screening... Read more

MRI

view channel

Image: PET/MRI can accurately classify prostate cancer patients (Photo courtesy of 123RF)

PET/MRI Improves Diagnostic Accuracy for Prostate Cancer Patients

The Prostate Imaging Reporting and Data System (PI-RADS) is a five-point scale to assess potential prostate cancer in MR images. PI-RADS category 3 which offers an unclear suggestion of clinically significant... Read more

Next Generation MR-Guided Focused Ultrasound Ushers In Future of Incisionless Neurosurgery

Essential tremor, often called familial, idiopathic, or benign tremor, leads to uncontrollable shaking that significantly affects a person’s life. When traditional medications do not alleviate symptoms,... Read more

Image: Shorter scan to diagnose prostate cancer can increase availability and reduce cost (Photo courtesy of 123RF)

Two-Part MRI Scan Detects Prostate Cancer More Quickly without Compromising Diagnostic Quality

Prostate cancer ranks as the most prevalent cancer among men. Over the last decade, the introduction of MRI scans has significantly transformed the diagnosis process, marking the most substantial advancement... Read more

World’s Most Powerful MRI Machine Images Living Brain with Unrivaled Clarity

The world's most powerful magnetic resonance imaging (MRI) scanner has generated its first images of the human brain, demonstrating new precision levels that could shed more light on the mysterious human... Read more

Ultrasound

view channel

Deep Learning Advances Super-Resolution Ultrasound Imaging

Ultrasound localization microscopy (ULM) is an advanced imaging technique that offers high-resolution visualization of microvascular structures. It employs microbubbles, FDA-approved contrast agents, injected... Read more

Image: Schematic diagram of the ultrasound-stimulated phase-shift nanoparticle drug delivery system for biofilm therapy (Photo courtesy of BIO Integration)

Novel Ultrasound-Launched Targeted Nanoparticle Eliminates Biofilm and Bacterial Infection

Biofilms, formed by bacteria aggregating into dense communities for protection against harsh environmental conditions, are a significant contributor to various infectious diseases. Biofilms frequently... Read more

AI-Guided Ultrasound System Enables Rapid Assessments of DVT

Deep vein thrombosis (DVT), a condition in which a blood clot is usually found in the leg, is a major cause of preventable hospital death in Europe and the United States. Patients have to wait for hours... Read more

Image: The QA protocol will ensure guided focused ultrasound devices and treatment is safe and function consistently (Photo courtesy of Chen Lab)

Focused Ultrasound Technique Gets Quality Assurance Protocol

In recent years, researchers have harnessed the potential of focused ultrasound (FUS) in combination with microbubbles to temporarily open the blood-brain barrier (BBB), a method that significantly enhances... Read more

General/Advanced Imaging

view channel

Image: The Tyche machine-learning model could help capture crucial information. (Photo courtesy of 123RF)

New AI Method Captures Uncertainty in Medical Images

In the field of biomedicine, segmentation is the process of annotating pixels from an important structure in medical images, such as organs or cells. Artificial Intelligence (AI) models are utilized to... Read more

CT Coronary Angiography Reduces Need for Invasive Tests to Diagnose Coronary Artery Disease

Coronary artery disease (CAD), one of the leading causes of death worldwide, involves the narrowing of coronary arteries due to atherosclerosis, resulting in insufficient blood flow to the heart muscle.... Read more

$Image: An amyloid blood test can help identify patients who may forgo imaging evaluation for Alzheimer\'s disease (Photo courtesy of 123RF)$

Novel Blood Test Could Reduce Need for PET Imaging of Patients with Alzheimer’s

Alzheimer's disease (AD), a condition marked by cognitive decline and the presence of beta-amyloid (Aβ) plaques and neurofibrillary tangles in the brain, poses diagnostic challenges. Amyloid positron emission... Read more

CT-Based Deep Learning Algorithm Accurately Differentiates Benign From Malignant Vertebral Fractures

The rise in the aging population is expected to result in a corresponding increase in the prevalence of vertebral fractures which can cause back pain or neurologic compromise, leading to impaired function... Read more

Imaging IT

view channel

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

An artificial intelligence (AI)-based mammography triage software is helping dramatically improve the interpretation process for healthcare providers. In a new study, researchers at the Scripps Green... Read more

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology.... Read more

Industry News

view channel

Bayer and Google Partner on New AI Product for Radiologists

Medical imaging data comprises around 90% of all healthcare data, and it is a highly complex and rich clinical data modality and serves as a vital tool for diagnosing patients. Each year, billions of medical... Read more

Image: Samsung Medison CEO Mr. Yongkwan Kim and Bracco Imaging CEO Dr. Fulvio Renoldi Bracco endorsed a MoU agreement (Photo courtesy of Bracco Group)

Samsung and Bracco Enter Into New Diagnostic Ultrasound Technology Agreement

Samsung Medison (Seoul, South Korea) and Bracco Imaging (Milan, Italy) have entered into a Memorandum of Understanding (MoU) agreement to pioneer a new area for diagnostic ultrasound devices and contrast agents.... Read more

Image: The acquisition will expand IBA’s medical imaging quality assurance offering (Photo courtesy of Radcal)

IBA Acquires Radcal to Expand Medical Imaging Quality Assurance Offering

Ion Beam Applications S.A. (IBA, Louvain-La-Neuve, Belgium), the global leader in particle accelerator technology and a world-leading provider of dosimetry and quality assurance (QA) solutions, has entered... Read more

International Societies Suggest Key Considerations for AI Radiology Tools

Artificial intelligence (AI) holds the potential to significantly disrupt the field of radiology, presenting both opportunities and challenges. Its integration could transform healthcare by enhancing the... Read more

1 (102.99682617188): SET sql_mode = 'MYSQL40'

2 (118.01719665527): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering

3 (413.89465332031): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294799800 ) ORDER BY menuid DESC LIMIT 1

4 (328.06396484375): DELETE FROM jos_session WHERE time < 1745942342 AND guest = 1 AND userid = 0

5 (46.014785766602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

6 (248.90899658203): SELECT * FROM jos_session WHERE session_id = 'bde8f43f0c810f442f11e0fa014902f0'

7 (376.93977355957): UPDATE jos_session SET `time`='1745943242',`userid`='0',`usertype`='\'\'',`username`='',`gid`='0',`guest`='1' WHERE session_id='bde8f43f0c810f442f11e0fa014902f0'

8 (396.9669342041): SELECT * FROM jos_menu WHERE id = 294799800

9 (952.95906066895): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

10 (92.029571533203): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

11 (!!!!! 1379.0130615234): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294799800) AND (fid=213) ORDER BY id DESC, `created` DESC LIMIT 0,16

12 (221.01402282715): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294799800) AND (fid=213) ORDER BY id DESC, `created` DESC LIMIT 0,16

13 (!!!!! 4760.0269317627): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=213 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294799800 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

14 (!!!!! 5162.9543304443): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=213 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294799800 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

15 (!!!!! 1802.921295166): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294799800 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

16 (!!!!! 1689.9108886719): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294799800 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

17 (445.84274291992): SELECT name,id,title FROM jos_deeppockets WHERE id=213 LIMIT 1

18 (159.97886657715): SELECT name,id,title FROM jos_deeppockets WHERE id=213 LIMIT 1

19 (658.98895263672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

20 (136.8522644043): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

21 (683.06922912598): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

22 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

23 (70.095062255859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

24 (!!!!! 1178.9798736572): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id

25 (421.04721069336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294799800 LIMIT 1

26 (48.87580871582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294799800 LIMIT 1

27 (!!!!! 3777.027130127): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1

28 (!!!!! 3962.9936218262): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1

29 (!!!!! 1109.1232299805): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294799800 ) ORDER BY ordering

30 (!!!!! 1416.9216156006): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

31 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

32 (91.075897216797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294799800 LIMIT 1

33 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294799800 LIMIT 1

34 (50.067901611328): select journal.name,journal.id,dpcat.livesite,journal.code from jos_dp_categories dpcat join jos_journal journal on journal.id=dpcat.journalid where dpcat.id=10

35 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

36 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

37 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

38 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

39 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

40 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

41 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

42 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

43 (459.90943908691): SELECT name FROM jos_deeppockets WHERE id=294799800 LIMIT 1

44 (79.154968261719): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

45 (675.20141601562): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

46 (!!!!! 1607.8948974609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

47 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

48 (169.03877258301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

49 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

50 (140.19012451172): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

51 (689.02969360352): SELECT fid FROM jos_deeppockets WHERE id=294799800 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799800 AND published='1' LIMIT 1

52 (422.95455932617): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

53 (66.041946411133): select jos_twitters.link from jos_twitters where cat=10

54 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

55 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

56 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

57 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE id=294799800 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799800 AND published='1' LIMIT 1

58 (44.107437133789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

59 (386.95335388184): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799800 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

60 (!!!!! 11908.054351807): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

61 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

62 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

63 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

64 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

65 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

66 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

67 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

68 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

69 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

70 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

71 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

72 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

73 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (66.041946411133): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799800 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

92 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

93 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

95 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

96 (529.05082702637): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (828.02772521973): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (542.87910461426): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (177.14500427246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

100 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

101 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

102 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

103 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

104 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

105 (478.02925109863): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

106 (!!!!! 75452.089309692): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

107 (422.00088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

108 (473.97613525391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

109 (!!!!! 1713.0374908447): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799800 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799800 AND type='deeppockets_item' AND published='1' LIMIT 1

110 (!!!!! 566162.109375): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (101.08947753906): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (412.94097900391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (147.10426330566): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (319.00405883789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (86.069107055664): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (272.98927307129): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (429.15344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

119 (123.97766113281): SELECT name FROM jos_deeppockets WHERE id=213

120 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=213

121 (509.97734069824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (394.82116699219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

124 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

125 (!!!!! 25046.110153198): TRUNCATE TABLE jos_trademed_module

126 (156.87942504883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799800 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

127 (625.8487701416): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (135.18333435059): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

130 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

131 (!!!!! 1419.0673828125): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

132 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

133 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

134 (49.829483032227): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799800 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799800 AND type='deeppockets_item' AND published='1' LIMIT 1

135 (29.087066650391): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

136 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

138 (148.05793762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

139 (173.09188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799800 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799800 AND published='1' LIMIT 1

140 (149.96528625488): select jos_twitters.link from jos_twitters where cat=10

141 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

142 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

143 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

144 (370.02563476562): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

145 (!!!!! 4974.8420715332): insert into jos_banners_delta values (14615,'2025-04-29 16:14:03','18.216.207.192','view'),(14202,'2025-04-29 16:14:03','18.216.207.192','view'),(14203,'2025-04-29 16:14:03','18.216.207.192','view')

Download Mobile App

Video Library

New PET Tracer Noninvasively Identifies Cancer Gene Mutation for More Precise Diagnosis

Latest Nuclear Medicine News

Channels

Radiography

Novel Breast Imaging System Proves As Effective As Mammography

AI Assistance Improves Breast-Cancer Screening by Reducing False Positives

AI Could Boost Clinical Adoption of Chest DDR

3D Mammography Almost Halves Breast Cancer Incidence between Two Screening Tests

MRI

PET/MRI Improves Diagnostic Accuracy for Prostate Cancer Patients

Next Generation MR-Guided Focused Ultrasound Ushers In Future of Incisionless Neurosurgery

Two-Part MRI Scan Detects Prostate Cancer More Quickly without Compromising Diagnostic Quality

World’s Most Powerful MRI Machine Images Living Brain with Unrivaled Clarity

Ultrasound

Deep Learning Advances Super-Resolution Ultrasound Imaging

Novel Ultrasound-Launched Targeted Nanoparticle Eliminates Biofilm and Bacterial Infection

AI-Guided Ultrasound System Enables Rapid Assessments of DVT

Focused Ultrasound Technique Gets Quality Assurance Protocol

General/Advanced Imaging

New AI Method Captures Uncertainty in Medical Images

CT Coronary Angiography Reduces Need for Invasive Tests to Diagnose Coronary Artery Disease

Novel Blood Test Could Reduce Need for PET Imaging of Patients with Alzheimer’s

CT-Based Deep Learning Algorithm Accurately Differentiates Benign From Malignant Vertebral Fractures

Imaging IT

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

Industry News

Bayer and Google Partner on New AI Product for Radiologists

Samsung and Bracco Enter Into New Diagnostic Ultrasound Technology Agreement

IBA Acquires Radcal to Expand Medical Imaging Quality Assurance Offering

International Societies Suggest Key Considerations for AI Radiology Tools

MedImaging

Channels

Features

Partner Sites

Archive:

Click for LinkXpress Reader Inquiry Service
Enter code to receive information:

Where I can find code?

LinkXpress

Download Mobile App

Video Library

New PET Tracer Noninvasively Identifies Cancer Gene Mutation for More Precise Diagnosis

Latest Nuclear Medicine News

Channels

MedImaging

Channels

Features

Partner Sites

Archive: