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Novel PET Tracer Enhances Lesion Detection in Medullary Thyroid Cancer

By MedImaging International staff writers
Posted on 22 Jan 2024

Image: A newly developed PET imaging agent is effective in identifying medullary thyroid cancer (Photo courtesy of 123RF)

Medullary thyroid cancer (MTC) represents about 3% of all thyroid cancer cases and is notably rare. It arises from different cells compared to other thyroid cancers, necessitating distinct imaging and treatment approaches. The overexpression of the cholecystokinin-2 receptor (CCK-2R) on most MTC cells has led to the development of various compounds targeting this receptor. However, many of these compounds suffer from low metabolic stability, which hampers their effectiveness in radioligand therapy. Now, a newly developed PET imaging agent has shown promise in both preclinical and clinical studies for identifying MTC, suggesting its potential as a theranostic tool in clinical settings.

In a study conducted by researchers at Stanford University (Stanford, CA, USA), three compounds—DOTA-CCK-66, DOTA-CCK 66.2, and DOTA-MGS5—were each labeled with different isotopes: 64Cu, 67Ga, and 177Lu. The team evaluated the CCK-2R affinity of these radiolabeled compounds on MTC cells. All compounds displayed high affinity, but DOTA-CCK-66 was selected for further study due to its superior in vitro properties, leading to the exclusion of DOTA-CCK-66.2 from subsequent analyses.

Following this, the researchers carried out in vivo stability, biodistribution, imaging, and competition studies using mice with CCK-2R-expressing tumors. Based on its comprehensive in vitro and in vivo performance, 68Ga-DOTA-CCK-66 was chosen for a proof-of-concept PET/CT application. Subsequently, two MTC patients underwent 68Ga-DOTA-CCK-66 PET/CT scans. The scans revealed that the compound was well tolerated by the patients, exhibited favorable biodistribution, and demonstrated high activity accumulation in the tumors.

“Due to increased in vivo stability, our compound reveals favorable tumor uptake as well as an improved activity clearance from off-target tissues,” said Constantin Lapa, MD, director of nuclear medicine at University Hospital Augsburg. “This could result in enhanced lesion detection in PET imaging and additionally enable targeted MTC radioligand therapy.”

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92 (571.96617126465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

93 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

94 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799971 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

95 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

96 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

97 (336.88545227051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799971 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (579.1187286377): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (349.99847412109): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

101 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

102 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

103 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

104 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

105 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

106 (287.05596923828): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 47878.980636597): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (369.07196044922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

109 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

110 (540.97175598145): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799971 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799971 AND type='deeppockets_item' AND published='1' LIMIT 1

111 (!!!!! 777483.22486877): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (108.00361633301): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

115 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

117 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

119 (609.15946960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (319.00405883789): SELECT name FROM jos_deeppockets WHERE id=213

121 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=213

122 (455.14106750488): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (417.94776916504): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

125 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

126 (!!!!! 8904.9339294434): TRUNCATE TABLE jos_trademed_module

127 (159.02519226074): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799971 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (642.06123352051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

131 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

132 (!!!!! 1482.0098876953): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

134 (147.81951904297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

135 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799971 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799971 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (45.061111450195): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

138 (49.114227294922): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

140 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799971 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799971 AND published='1' LIMIT 1

141 (49.829483032227): select jos_twitters.link from jos_twitters where cat=10

142 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

143 (33.140182495117): select jos_google_plus.link from jos_google_plus where cat=10

144 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

145 (232.93495178223): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 1265.0489807129): insert into jos_banners_delta values (14615,'2025-04-29 16:31:41','18.218.226.136','view'),(14202,'2025-04-29 16:31:41','18.218.226.136','view'),(14203,'2025-04-29 16:31:41','18.218.226.136','view')

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