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Medical Imaging Technique Enables Accurate Visualization of Tumor-Targeting Bacteria

By MedImaging International staff writers
Posted on 27 Oct 2023

For close to 100 years, science has shown that using particular bacteria to zero in on cancer tumors can help activate the immune system, aiding in cancer treatment. This method has especially been effective in treating bladder cancer while sparing healthy tissues, unlike conventional radiation and chemotherapy. Now, a study to advance the application of such bacterial cancer therapies has led to the development of a new technique to accurately image how these bacterial treatments navigate the body and target breast cancer.

The research team at Johns Hopkins Medicine (Baltimore, MD, USA) had earlier developed an imaging technology that could precisely track bacterial therapies inside the body. This technology involves a molecule known as 18F-Fluorodeoxysorbitol, or 18F-FDS, which bacterial cells readily absorb. Once inside the bacteria, this molecule enables the cells to become visible on PET and CT scans, revealing their location within the body. The team conducted experiments on rodent models with breast cancer, employing their 18F-FDS PET imaging technique. They specifically looked into whether a unique strain of Y. enterocolitica bacteria could target breast cancer tumors and be visualized using their imaging method..

The researchers began by injecting the special Y. enterocolitica strain into mice that had breast cancer. Next, these mice were given an additional injection of the 18F-FDS tracer to get them ready for imaging scans. The mice were then scanned at various time intervals, including days one, five, and ten, using both PET and CT imaging technologies. The scans showed that the Y. enterocolitica strain did effectively target and take up residence in breast cancer tumors. Furthermore, the 18F-FDS tracer enabled precise imaging of where these bacterial cells were located within the mice.

“We are able to use this imaging technology to track the bacteria and make sure the bacterial infection is not sitting in other healthy tissues,” said Sanjay Jain, M.B.B.S., M.D., professor of pediatrics at the Johns Hopkins University School of Medicine. “The technology is helpful in developing these bacterial therapies for cancers, which is what we showed here with the bacteria Yersinia enterocolitica and breast cancer.”

“Being able to use PET imaging to visualize tumor-targeting bacteria will enable faster development and implementation of this innovative tool for oncologic patients,” added Alvaro Ordoñez, M.D., assistant professor of medicine at the Johns Hopkins University School of Medicine.

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84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

93 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

94 (399.11270141602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799115 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

95 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

96 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

97 (!!!!! 3441.8106079102): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799115 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (622.98774719238): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (360.96572875977): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

101 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

102 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

103 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

104 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

105 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

106 (295.87745666504): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 43891.906738281): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

109 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

110 (411.03363037109): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799115 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799115 AND type='deeppockets_item' AND published='1' LIMIT 1

111 (!!!!! 932481.05049133): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (128.98445129395): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (869.0357208252): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (146.15058898926): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

115 (646.11434936523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (131.13021850586): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

117 (632.04765319824): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (172.13821411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

119 (257.01522827148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (97.036361694336): SELECT name FROM jos_deeppockets WHERE id=213

121 (111.10305786133): SELECT name FROM jos_deeppockets WHERE id=213

122 (419.13986206055): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (327.82554626465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

125 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

126 (!!!!! 5887.0315551758): TRUNCATE TABLE jos_trademed_module

127 (371.93298339844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799115 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (534.0576171875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

131 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

132 (!!!!! 1069.0689086914): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

134 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

135 (253.91578674316): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799115 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799115 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (469.92301940918): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (!!!!! 1011.1331939697): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

138 (37.908554077148): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

140 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799115 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799115 AND published='1' LIMIT 1

141 (154.01840209961): select jos_twitters.link from jos_twitters where cat=10

142 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10

143 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

144 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

145 (412.94097900391): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 2996.9215393066): insert into jos_banners_delta values (14615,'2025-04-29 15:48:55','18.222.24.251','view'),(14202,'2025-04-29 15:48:55','18.222.24.251','view'),(14203,'2025-04-29 15:48:55','18.222.24.251','view')

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