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MRI-Guided Radiotherapy for Prostate Cancer Improves Treatment Accuracy

By MedImaging International staff writers
Posted on 25 Jul 2023

Image: Image-guided adaptive radiation treatments can reduce short-term side effects for prostate cancer patients (Photo courtesy of Freepik)

Stereotactic body radiotherapy (SBRT) is increasingly being used for managing prostate cancer, although conventional techniques present considerable toxicity risks. The use of magnetic resonance-guided daily adaptive SBRT (MRg-A-SBRT) brings technological advantages in radiation dose delivery precision, but its toxicity profile compared to the more frequently used computed tomography-guided non-adaptive prostate SBRT (CT-SBRT) has remained unexplored. Now, researchers have found that MRg-A-SBRT can significantly improve radiation therapy safety for prostate cancer patients. This method, by using imaging technology as a guide, allows clinicians to accurately target radiation beams at the prostate, reducing exposure to nearby tissues in the bladder, urethra, and rectum.

These insights have emerged from an exhaustive analysis of all published clinical trials of MRg-A-SBRT conducted by researchers at the Dana-Farber/Brigham and Women's Cancer Center (Boston, MA, USA). The team thoroughly examined the efficacy of MRg-A-SBRT for prostate cancer treatment, meticulously searching the medical literature for prospective studies that had evaluated MRg-A-SBRT. They combined data from 29 clinical trials involving a total of 2,547 patients, and compared the side effects of MRg-A-SBRT with a more conventional treatment approach that utilized CT-SBRT but did not involve daily adjustments like MRg-A-SBRT.

Their analysis revealed that MRg-A-SBRT led to significantly fewer urinary and bowel side effects over the short term following radiation treatment. Specifically, urinary side effects saw a significant 44% reduction, while bowel side effects decreased by a remarkable 60%. This research, the first of its kind to directly compare the advantages of MR-guided adaptive prostate radiation with a more standard and conventional form of radiation, strongly endorses the use of MRg-A-SBRT as an efficient treatment option for managing prostate cancer.

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71 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294798026 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294798026 AND published='1' LIMIT 1

72 (28.848648071289): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

73 (157.11784362793): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (145.91217041016): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (!!!!! 11858.940124512): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (26.941299438477): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (30.994415283203): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

108 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

109 (53.167343139648): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798026 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (42.915344238281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798026 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (569.82040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

112 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

113 (107.0499420166): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798026 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (406.02684020996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798026 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (626.80244445801): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (426.05400085449): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

118 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

119 (163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

120 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

121 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

122 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

123 (216.00723266602): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 38680.076599121): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (!!!!! 6601.095199585): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

126 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

127 (482.79762268066): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798026 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798026 AND type='deeppockets_item' AND published='1' LIMIT 1

128 (!!!!! 688675.88043213): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (118.97087097168): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (346.89903259277): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

131 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (350.9521484375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

133 (64.13459777832): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (254.86946105957): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

135 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (455.85632324219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (314.95094299316): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (301.83792114258): SELECT name FROM jos_deeppockets WHERE id=213

139 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=213

140 (447.98851013184): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (333.07075500488): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

143 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

144 (!!!!! 7330.8944702148): TRUNCATE TABLE jos_trademed_module

145 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798026 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798026 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (778.1982421875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

150 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

151 (!!!!! 1123.9051818848): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

153 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

154 (80.82389831543): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798026 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798026 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (27.894973754883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

157 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

159 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798026 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798026 AND published='1' LIMIT 1

160 (107.0499420166): select jos_twitters.link from jos_twitters where cat=10

161 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

162 (27.894973754883): select jos_google_plus.link from jos_google_plus where cat=10

163 (92.029571533203): select jos_linkedin.link from jos_linkedin where cat=10

164 (249.14741516113): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

165 (!!!!! 1044.9886322021): insert into jos_banners_delta values (14615,'2025-04-29 23:38:47','13.59.96.255','view'),(14202,'2025-04-29 23:38:47','13.59.96.255','view'),(14203,'2025-04-29 23:38:47','13.59.96.255','view')

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