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Molecular Imaging Technique Improves Endometriosis Diagnosis

By MedImaging International staff writers
Posted on 08 Jun 2022

Endometriosis is a common inflammatory condition affecting women, associated with painful periods, chronic pelvic pain, and infertility. It is believed to be due to tissue that resembles the lining of the womb sticking to areas outside the uterus, usually in the pelvis. However, diagnosing endometriosis often results in multiple visits to physicians, multiple scans and often surgery to confirm the diagnosis. As a result, there is a delay to get a diagnosis of endometriosis, mainly due to lack of non-invasive tests capable of detecting all endometriosis subtypes (ovarian, superficial, and deep disease). Now, a new research study is investigating whether a 20-minute imaging scan can detect the most common types of endometriosis, which currently require surgery to diagnose.

Endometriosis experts at the University of Oxford (Oxford, UK) have joined hands with Serac Healthcare Ltd. (London, UK) to investigate whether an experimental imaging marker (⁹⁹ᵐTc maraciclatide) that binds to areas of inflammation can be used in endometriosis to visualize the disease on a scan. The imaging marker has been used for detecting inflammation in conditions such as rheumatoid arthritis in other research studies across the UK, EU and US. Maraciclatide is for investigational use only and is not approved by the FDA or UK and European regulatory authorities.

The potential strengths of the scan lie in the way the imaging marker binds to areas of inflammation, which may allow doctors to distinguish between new and old lesions and detect endometriosis in areas not easily seen during surgery such as the lung. The development of a 20-minute imaging test would reduce the need for repeated visits to doctors, for repeated investigations, and for invasive surgery to obtain a diagnosis. This would ultimately reduce the time taken to confirm or exclude endometriosis.

Initially, the study will involve women who are scheduled to have planned surgery for suspected endometriosis. Two to seven days before their operation, the participants will be invited for an imaging scan which will compare the suspected locations of disease detected on the scan and in surgery to confirm whether this imaging test could be an effective non-invasive method of detecting all endometriosis subtypes.

“There is an urgent unmet clinical need for a non-invasive marker to identify or rule out endometriosis as it is such a very common disease affecting more than 190 million women worldwide,” said Professor Christian Becker, Co-Director of the Endometriosis CaRe Centre in Oxford, who will lead the study.

“We are excited about the potential of ⁹⁹ᵐTc maraciclatide to diagnose endometriosis non-invasively and delighted to be working with the internationally renowned team at Oxford on this important first study,” said David Hail, CEO of Serac Healthcare.

Related Links:
University of Oxford
Serac Healthcare Ltd.

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59 (561.95259094238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 1121.997833252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

61 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

62 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

63 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

64 (78.201293945312): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (492.81120300293): SELECT fid FROM jos_deeppockets WHERE id=294793300 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294793300 AND published='1' LIMIT 1

66 (355.00526428223): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

67 (44.822692871094): select jos_twitters.link from jos_twitters where cat=10

68 (28.848648071289): select jos_facebook.link from jos_facebook where cat=10

69 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

70 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

71 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294793300 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294793300 AND published='1' LIMIT 1

72 (30.040740966797): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

73 (250.10108947754): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (252.00843811035): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

108 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

109 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (44.822692871094): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

112 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

113 (419.13986206055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (347.13745117188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294793283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (321.86508178711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294793283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (552.17742919922): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (313.99726867676): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

120 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

121 (174.04556274414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

122 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

123 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

124 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

125 (287.05596923828): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 19470.930099487): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

128 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

129 (413.89465332031): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294793300 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294793300 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 400995.01609802): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (73.19450378418): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

136 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

138 (483.98971557617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (339.03121948242): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (204.08630371094): SELECT name FROM jos_deeppockets WHERE id=213

141 (33.140182495117): SELECT name FROM jos_deeppockets WHERE id=213

142 (427.9613494873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (334.9781036377): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

145 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

146 (!!!!! 7941.0076141357): TRUNCATE TABLE jos_trademed_module

147 (102.04315185547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294793300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (853.06167602539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

152 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

153 (!!!!! 1045.9423065186): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

155 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

156 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294793300 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294793300 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

158 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (367.87986755371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

161 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294793300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294793300 AND published='1' LIMIT 1

162 (37.908554077148): select jos_twitters.link from jos_twitters where cat=10

163 (32.186508178711): select jos_facebook.link from jos_facebook where cat=10

164 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

165 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

166 (260.82992553711): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

167 (!!!!! 3159.0461730957): insert into jos_banners_delta values (14615,'2025-04-29 22:54:49','3.135.237.153','view'),(14202,'2025-04-29 22:54:49','3.135.237.153','view'),(14203,'2025-04-29 22:54:49','3.135.237.153','view')

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