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Novel Nuclear Imaging Probe Rapidly Assesses Treatment Response in Gastric Cancer

By MedImaging International staff writers
Posted on 13 Jan 2022

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A novel nuclear imaging probe can measure a gastric cancer patient’s response to treatment within days, marking a potential breakthrough that could enable patients who aren’t responding to treatment to get moved quickly to potentially more effective therapies.

Researchers at the Massachusetts General Hospital (Boston, MA, USA) developed the nuclear imaging probe that combines the radioisotope gallium with a peptide specific for a protein called human epidermal growth factor 3 (HER3). The probe was developed to guide the addition of anti-HER3 inhibitors to the standard HER2 inhibition therapy. It enables measurements of HER3 levels by binding to gallium, which can be detected on PET scans.

Gastric cancer, also referred to as stomach cancer, is the fourth most common cancer and the second leading cause of cancer death worldwide. Most gastric cancers express HER2 that promotes the growth of cancer cells. In recent years, treatments targeting HER2 have emerged as potentially effective options for many gastric cancer patients. Anti-HER2 treatment often fails, however, due to the activation of HER3. Clinically, HER3 is expressed in more than a third of gastric cancers and is associated with poor prognosis, cancer spread and recurrence. The ability to identify the patients who are more likely to respond to anti-HER2 therapy would be hugely beneficial, sparing many patients from the time, expense and side effects of an ultimately ineffective treatment. Unfortunately, current imaging-based treatment assessments have limitations.

The researchers tested the probe on several gastric cancer sublines, beginning with a cell culture and using different doses of the same drug. HER3 levels did not increase in cancers that were resistant to treatment, while an elevation of HER3 was seen in the cancers responsive to that treatment. The team then planted a treatment-resistant and a treatment-responsive cell line in mice. The researchers treated the mice with the same drug and then imaged them before and after treatment with the HER3-targeting probe. Within four days of treatment, there was a significant increase in the PET activity in the mice with the treatment-sensitive cancer line, compared with no significant change in those with the treatment-resistant cancer.

Now that the probe has been tested in multiple mouse models, the researchers want to use it in clinical trials for patients with gastric cancer. It could also provide treatment assessment in patients with other solid tumor types that have HER3 on their surface, such as in certain thyroid, breast and lung cancers, to stratify the patients who might benefit from addition of anti-HER3 inhibitors to the treatment regimen. The researchers also discovered through the research that gastric tumors metabolize glucose differently.

“Current imaging modalities show tumor size, but it may take weeks before any perceptible change is demonstrated that can indicate whether the treatment is working,” said Shadi Abdar Esfahani, MD, MPH, a nuclear medicine specialist and instructor in radiology at Massachusetts General Hospital in Boston. “We need new imaging approaches so that we can scan the patients within a few days after receiving treatment to see if it’s working or not.”

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61 (388.86070251465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

62 (!!!!! 1064.0621185303): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

63 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

64 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

65 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

66 (69.141387939453): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

67 (514.03045654297): SELECT fid FROM jos_deeppockets WHERE id=294791228 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791228 AND published='1' LIMIT 1

68 (280.14183044434): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

69 (47.922134399414): select jos_twitters.link from jos_twitters where cat=10

70 (57.220458984375): select jos_facebook.link from jos_facebook where cat=10

71 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

72 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

73 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294791228 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791228 AND published='1' LIMIT 1

74 (30.040740966797): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

75 (265.12145996094): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (200.98686218262): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (33.855438232422): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

95 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

110 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

111 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

114 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

115 (398.87428283691): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (339.03121948242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791225 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (316.85829162598): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791225 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (540.97175598145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

120 (348.09112548828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

122 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

123 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

124 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

125 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

126 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

127 (232.93495178223): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

128 (!!!!! 17750.978469849): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

129 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

130 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

131 (373.84033203125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791228 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791228 AND type='deeppockets_item' AND published='1' LIMIT 1

132 (!!!!! 398212.19444275): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

133 (74.863433837891): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

135 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

136 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

137 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

138 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

139 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

140 (478.02925109863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (337.12387084961): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (216.00723266602): SELECT name FROM jos_deeppockets WHERE id=213

143 (33.855438232422): SELECT name FROM jos_deeppockets WHERE id=213

144 (430.10711669922): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (364.06517028809): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

147 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

148 (!!!!! 7846.1170196533): TRUNCATE TABLE jos_trademed_module

149 (104.18891906738): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791228 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (814.91470336914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

154 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

155 (!!!!! 1083.1356048584): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

156 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

157 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

158 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791228 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791228 AND type='deeppockets_item' AND published='1' LIMIT 1

159 (29.087066650391): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (27.179718017578): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

161 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

162 (537.87231445312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

163 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791228 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791228 AND published='1' LIMIT 1

164 (42.200088500977): select jos_twitters.link from jos_twitters where cat=10

165 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

166 (31.232833862305): select jos_google_plus.link from jos_google_plus where cat=10

167 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

168 (277.04238891602): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

169 (!!!!! 1276.969909668): insert into jos_banners_delta values (14615,'2025-04-29 23:42:16','3.145.175.71','view'),(14202,'2025-04-29 23:42:16','3.145.175.71','view'),(14203,'2025-04-29 23:42:16','3.145.175.71','view')

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