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Novel Sonic Beam Therapy Liquefies Tumor Tissues

By MedImaging International staff writers
Posted on 01 Nov 2021

Image: The Edison histotripsy sonic beam platform (Photo courtesy of Histonics)

An automated external beam system uses acoustic energy to mechanically destroy tissue in the liver without incisions, ionizing radiation, or heat.

The HistoSonics (Minneapolis, MN, USA) Edison is a sophisticated histotripsy sonic beam platform designed to deliver pulsed sound energy into the body, without any incisions or needles, that destroys tissue at the sub-cellular level. Physicians first contour and plan treatment according to shape and size of their target; once the energy required to initiate cellular destruction is determined, the acoustic pulses are delivered. Treatment is monitored in real-time, while the system automatically moves through the target area.

Histotripsy uses pulsed sound waves to induce microbubbles from gases that are naturally present in tissues. These “bubble clouds” form and collapse in microseconds, creating mechanical forces that are strong enough to destroy tissue in a non-invasive and non-thermal method. As only 20%-30% of patients with liver tumors are eligible for surgical resection, due to the presence of multiple tumors, underlying poor liver function, or general health issues, histotripsy may provide a solution. Edison has received breakthrough device designation from the U.S. Food and Drug Administration (FDA).

“The Breakthrough Device Designation is a significant milestone for our company and validates our belief that our platform offers significant advantages over existing approved or cleared alternatives,” said Mike Blue, President and CEO of HistoSonics. “Early and ongoing clinical results are promising and suggest that our ability to precisely destroy targeted liver tissue, completely non-invasively, and without the challenges associated with ionizing radiation or other locoregional therapies, provides advantages to patients and physicians that don't exist today.”

Primary liver tumors were the third leading cause of tumor related death worldwide in 2020, with approximately 906,000 new cases and 830,000 deaths globally, and 5-year survival rates less than 18%. Additionally, the liver is second only to lymph nodes as the most common site of metastatic tumors, and estimated to be present in up to 70% of patients with advanced disease from another site.

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69 (558.13789367676): SELECT fid FROM jos_deeppockets WHERE id=294790346 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294790346 AND published='1' LIMIT 1

70 (328.06396484375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

71 (125.88500976562): select jos_twitters.link from jos_twitters where cat=10

72 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

73 (29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10

74 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

75 (30.040740966797): SELECT fid FROM jos_deeppockets WHERE id=294790346 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294790346 AND published='1' LIMIT 1

76 (32.186508178711): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

77 (292.06275939941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

78 (211.00044250488): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

79 (43.153762817383): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

80 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

95 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

96 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

97 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

110 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

111 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

112 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

113 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790346 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790346 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

116 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

117 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790346 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (461.10153198242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790346 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (569.10514831543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

120 (324.01084899902): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

122 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

123 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

124 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

125 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

126 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

127 (277.99606323242): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

128 (!!!!! 19116.878509521): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

129 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

130 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

131 (478.98292541504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790346 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790346 AND type='deeppockets_item' AND published='1' LIMIT 1

132 (!!!!! 395670.89080811): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

133 (68.902969360352): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

136 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

137 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

138 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

139 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

140 (535.96496582031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (351.90582275391): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (206.94732666016): SELECT name FROM jos_deeppockets WHERE id=213

143 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=213

144 (600.09956359863): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (380.9928894043): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

147 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

148 (!!!!! 8132.9345703125): TRUNCATE TABLE jos_trademed_module

149 (87.976455688477): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790346 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790346 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (833.98818969727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

154 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

155 (!!!!! 1012.8021240234): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

156 (52.213668823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

157 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

158 (36.954879760742): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790346 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790346 AND type='deeppockets_item' AND published='1' LIMIT 1

159 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

160 (28.133392333984): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

161 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

162 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

163 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790346 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790346 AND published='1' LIMIT 1

164 (38.14697265625): select jos_twitters.link from jos_twitters where cat=10

165 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

166 (29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10

167 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

168 (226.02081298828): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

169 (!!!!! 1119.85206604): insert into jos_banners_delta values (14615,'2025-04-29 23:48:56','3.143.214.100','view'),(14202,'2025-04-29 23:48:56','3.143.214.100','view'),(14203,'2025-04-29 23:48:56','3.143.214.100','view')

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