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New Tumor-Targeting Agent Images a Wide Range of Cancers

By MedImaging International staff writers
Posted on 30 Jun 2014

Scientists reported that a new type of tumor-targeting agent can search out and target dozens of solid tumors, even illuminating brain cancer stem cells that do not respond to current treatments.

Moreover, years of animal studies and early human clinical trials show that this tumor-targeting, alkylphosphocholine (APC) molecule can deliver two types of “cargoes” right to cancer cells: a radioactive or fluorescent imaging label, or a radioactive medicine that binds and destroys cancer cells.

The study’s findings were reported in the June 13, 2014, issue of the journal Science Translational Medicine. The APC targeting platform is a synthetic molecule that exploits a weakness common to cancers as diverse as breast, lung, brain, and melanoma. These cancer cells lack the enzymes to metabolize phospholipid ethers, a cell membrane component that is easily cleared by normal cells. When administered in an intravenous solution, APC goes throughout the body—even across the blood-brain barrier—and adhere to the membrane of cancer cells. The cancer cells take up the APC and the imaging or treatment medication riding on the molecular platform, and retain it for days to weeks, resulting in direct cancer cell imaging or treatment.

The APC analogs were able to tag 55 of 57 different cancers. This large study had multiple stages, including testing in cancer cell lines, in rodents and rodents infected with human and rodent cancers, and in human patients with different cancers such as colorectal, breast, lung, and glioblastoma.

“I was a skeptic; it’s almost too good to be true,” said co-lead author Dr. John S. Kuo, associate professor of neurosurgery and director of the comprehensive brain tumor program at the University of Wisconsin (UW) School of Medicine and Public Health (Madison, USA). “It is a very broad cancer-targeting agent in terms of the many different cancers that tested positive. The APC analogs even sometimes revealed other sites of cancer in patients that were small, asymptomatic and previously undetected by physicians.”

Dr. Kuo specializes in the treatment of brain tumors, and also leads the UWCCC CNS Tumors group that are conducting many clinical trials for glioma, a brain cancer that is incurable because current treatments leave behind cancer stem cells that can seed and regrow the cancer. He noted that it was encouraging that the APC analogs also captured cancer stem cells and will also likely target them for additional treatment. “It’s also potentially superior to current imaging methods because the standard clinical MR or PET imaging may give false-positive results due to surgical scars, post-treatment effects, inflammation, or even infection, making it difficult to know if the cancer has truly returned,” he stated.

Dr. Kuo noted that the fluorescent intraoperative APC imaging might help make cancer surgeries more effective and safer; any cancer cells that cannot be safely removed can be targeted afterwards with radioactive APC therapy. In addition, APC imaging might avoid the false-positive findings of current imaging, so cancer patients can stay on effective therapies and likely avoid the risks and costs of “second look” surgeries.

The large multidisciplinary study team was also led by co-lead author Dr. Jamey P. Weichert, associate professor of radiology, who cofounded and serves as chief scientific officer of Cellectar Biosciences, Inc., a Madison-based company developing the APC analog platform for cancer imaging and therapy.

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University of Wisconsin School of Medicine and Public Health

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64 (!!!!! 7936.954498291): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

65 (!!!!! 11667.966842651): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

66 (348.09112548828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

67 (589.13230895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

68 (461.10153198242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

69 (898.83804321289): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

70 (561.95259094238): SELECT fid FROM jos_deeppockets WHERE id=294753275 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753275 AND published='1' LIMIT 1

71 (460.86311340332): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

72 (607.01370239258): select jos_twitters.link from jos_twitters where cat=10

73 (!!!!! 6007.9097747803): select jos_facebook.link from jos_facebook where cat=10

74 (130.89179992676): select jos_google_plus.link from jos_google_plus where cat=10

75 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

76 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE id=294753275 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753275 AND published='1' LIMIT 1

77 (123.97766113281): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

78 (365.9725189209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

79 (602.96058654785): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

80 (338.07754516602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

81 (136.13700866699): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (308.99047851562): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 2935.1711273193): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 2502.9182434082): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

96 (27.894973754883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

97 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

98 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

110 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

111 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

112 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

113 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

114 (97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (!!!!! 2707.0045471191): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

117 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

118 (49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (!!!!! 4067.8977966309): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

120 (602.00691223145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (346.89903259277): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

122 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

123 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

124 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

125 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

126 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

127 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

128 (359.05838012695): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

129 (!!!!! 120075.94108582): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

130 (!!!!! 3591.0606384277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

131 (!!!!! 2121.9253540039): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

132 (603.91426086426): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753275 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753275 AND type='deeppockets_item' AND published='1' LIMIT 1

133 (!!!!! 4535.9134674072): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (375.98609924316): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

135 (406.02684020996): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

136 (305.8910369873): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

137 (257.96890258789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

138 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

139 (200.98686218262): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

140 (167.8466796875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

141 (317.09671020508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (280.85708618164): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=213

144 (29.087066650391): SELECT name FROM jos_deeppockets WHERE id=213

145 (422.00088500977): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (332.11708068848): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

147 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

148 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

149 (!!!!! 3773.9276885986): TRUNCATE TABLE jos_trademed_module

150 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (651.83639526367): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753275 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

152 (492.81120300293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

154 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

155 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

156 (!!!!! 1080.9898376465): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

157 (148.05793762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

158 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

159 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753275 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753275 AND type='deeppockets_item' AND published='1' LIMIT 1

160 (48.87580871582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

161 (48.160552978516): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

162 (30.994415283203): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

163 (151.15737915039): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

164 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753275 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753275 AND published='1' LIMIT 1

165 (76.055526733398): select jos_twitters.link from jos_twitters where cat=10

166 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10

167 (47.922134399414): select jos_google_plus.link from jos_google_plus where cat=10

168 (45.061111450195): select jos_linkedin.link from jos_linkedin where cat=10

169 (!!!!! 2937.0784759521): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

170 (!!!!! 5692.9588317871): insert into jos_banners_delta values (14615,'2025-04-29 21:08:43','3.23.102.192','view'),(14202,'2025-04-29 21:08:43','3.23.102.192','view'),(14203,'2025-04-29 21:08:43','3.23.102.192','view')

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