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Integrated MPI/CT Platform Offers Anatomical Context

By MedImaging International staff writers
Posted on 17 Sep 2019

Image: The Momentum CT system (Photo courtesy of Magnetic Insight).

Innovative magnetic particle imaging (MPI) technology, unrelated to magnetic resonance imaging (MRI), quantitatively detects magnetic nanoparticles anywhere in the body with exceptional sensitivity.

The Magnetic Insight (Alameda, CA, USA) Momentum CT system is a fully integrated, self-shielded, pre-clinical MPI solution that uses high-field gradient main magnet geometry and the proprietary x-space reconstruction process to produce highly sensitive and high-resolution MPI images. The system’s intuitive workflow and robust reconstruction reliably produce high quality images, without the need for a dedicated operator. The Momentum CT system is currently approved for pre-clinical, non-human studies.

With its unique technical capabilities, MPI enables novel applications, such as the systemic tracking of therapeutic cells during the course of therapy, inflammation, and vascular function. Furthermore, the technology can leverage nanoparticles to both image functional events and administer localized hyperthermic tumor ablation treatments and heat-sensitive drug delivery. Other Magnetic Insight products include HYPER, a localized hyperthermia module; VIVOTRAX, a clinically approved MPI tracer; and RELAX, a particle relaxometry module, and co-registration software to support multimodal imaging.

“MPI lies at the intersection of nanotechnology and medical imaging, producing potentially life-saving diagnostic capabilities complimentary to other current medical imaging technologies. Co-registration in an all-in-one format of CT and MPI simplifies and accelerates the MPI workflow offering full context in diagnostic imaging,” said Anna Christensen, CEO of Magnetic Insight. “Magnetic Insight's CT platform is purposely designed for safe, low dose, high-quality images which complements MPI's groundbreaking enablement in the medical imaging field.”

MPI is currently used to investigate new cell therapy treatments, immunology, and cancer in preclinical research models. The technology quantitatively detects magnetic nanoparticles tracers anywhere in the body with exceptional contrast, sensitivity, and resolution to image functional events in the body. But while MPI offers high contrast detection of functional events in the body--such as cell trafficking to disease sites and inflammation--it does not image anatomical structures. By integrating CT, researchers will have the ability to identify precise locations of these events based on tissue and bone structures.

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71 (45.061111450195): select jos_linkedin.link from jos_linkedin where cat=10

72 (396.9669342041): SELECT fid FROM jos_deeppockets WHERE id=294779347 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294779347 AND published='1' LIMIT 1

73 (41.961669921875): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

74 (729.08401489258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (305.8910369873): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (262.02201843262): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (!!!!! 7912.1589660645): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (!!!!! 7893.0854797363): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 7998.9433288574): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 7907.8674316406): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 7987.9760742188): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 7916.2120819092): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 7993.9365386963): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 7909.0595245361): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 3702.1636962891): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (541.92543029785): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1707.0770263672): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (559.09156799316): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (305.8910369873): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (179.05235290527): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (311.13624572754): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (268.93615722656): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (272.03559875488): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (819.92149353027): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (550.98533630371): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (803.94744873047): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 3121.1376190186): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (510.93101501465): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (922.91831970215): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1506.0901641846): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (320.9114074707): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (375.98609924316): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (899.07646179199): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (128.98445129395): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (179.05235290527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

109 (142.09747314453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

110 (294.20852661133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (537.87231445312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1090.0497436523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

113 (303.03001403809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

114 (339.03121948242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (842.80967712402): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (483.98971557617): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (303.98368835449): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

119 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

120 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

121 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

122 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

123 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

124 (248.90899658203): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 133106.94694519): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (!!!!! 22573.947906494): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

127 (!!!!! 6150.9609222412): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

128 (!!!!! 7857.084274292): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779347 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779347 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 1343314.8860931): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (!!!!! 1405586.9579315): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (365.9725189209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (402.92739868164): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (337.12387084961): SELECT name FROM jos_deeppockets WHERE id=213

140 (152.1110534668): SELECT name FROM jos_deeppockets WHERE id=213

141 (693.08280944824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (!!!!! 1540.8992767334): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (!!!!! 3836.1549377441): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

144 (597.95379638672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

145 (!!!!! 16984.939575195): TRUNCATE TABLE jos_trademed_module

146 (579.833984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (375.98609924316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779347 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (360.96572875977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

151 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

152 (!!!!! 5562.0670318604): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (!!!!! 1026.1535644531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

154 (!!!!! 1795.0534820557): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

155 (!!!!! 4755.0201416016): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779347 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779347 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (494.95697021484): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

157 (!!!!! 3120.1839447021): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

158 (45.061111450195): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

160 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779347 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779347 AND published='1' LIMIT 1

161 (!!!!! 1025.915145874): select jos_twitters.link from jos_twitters where cat=10

162 (341.89224243164): select jos_facebook.link from jos_facebook where cat=10

163 (447.98851013184): select jos_google_plus.link from jos_google_plus where cat=10

164 (603.91426086426): select jos_linkedin.link from jos_linkedin where cat=10

165 (307.08312988281): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 10876.893997192): insert into jos_banners_delta values (14615,'2025-04-29 21:08:35','3.23.102.192','view'),(14202,'2025-04-29 21:08:35','3.23.102.192','view'),(14203,'2025-04-29 21:08:35','3.23.102.192','view')

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