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MRI Improves Diagnosis and Treatment of Prostate Cancer

By MedImaging International staff writers
Posted on 28 Mar 2024

Prostate cancer ranks as a leading cancer type among men. Suspected prostate cancer cases are usually identified through a prostate-specific antigen (PSA) test or a rectal examination. If cancer is suspected, a systematic biopsy is typically performed, involving the collection of 10 to 12 random tissue samples with the assistance of ultrasound for laboratory analysis. Despite the use of ultrasound, this method is invasive and carries the risk of missing cancerous areas, along with possible side effects like bleeding, difficulty urinating, and infection. semen or urine, difficulty urinating, and infection including potentially deadly sepsis in rare cases. Now, two multi-center studies using magnetic resonance imaging (MRI) are playing a major role in changing the diagnostic pathway for prostate cancer.

MRI employs strong magnetic fields and radiofrequency waves to produce detailed cross-sectional images that can reveal cancers other methods may overlook, identifying the cancer's size, location, and spread. Both multi-center studies led by Hamilton Health Sciences (HHS, Ontario, Canada) used MRI to improve the diagnosis and treatment for men going through a prostate cancer diagnosis. The ASIST study (2010-2015) examined whether MRI detected additional high-risk cancers when used along with the standard-of-care systematic biopsy. The positive results from the ASIST study led to the second PRECISE study (2015-2017) to examine whether MRI could determine the need for a biopsy.

The ASIST trial, involving 273 participants, investigated whether MRI, alongside standard systematic biopsies guided by ultrasound, could detect prostate cancer at a risk of becoming aggressive at a different rate than when using an ultrasound-guided biopsy process alone. The study revealed MRI’s potential for helping to distinguish between patients who could benefit from aggressive treatment and those who are more ideal for regular monitoring, as many prostate cancers are not aggressive. The PRECISE trial, with 453 male participants, evaluated the necessity of biopsies in all suspected prostate cancer cases. It demonstrated that MRI could target two to four specific tissue samples from areas appearing cancerous, as opposed to the traditional method of collecting 10 to 12 random samples. This targeted approach not only reduces invasiveness but also minimizes recovery time and side effects, enhancing the detection of high-risk diseases while helping some patients avoid unnecessary radical treatments. In the PRECISE study, 37% of patients (79 individuals) were spared a biopsy after an MRI assessment indicated it was unnecessary.

“By providing MRI first, only those men who need a biopsy receive it,” said HHS researcher Dr. Gregory Pond who is the lead statistician and co-investigator for the two clinical trials. “It’s basically a win-win because we’re picking up the same amount of cancers as the systematic biopsy using ultrasound, but by doing the MRI first it’s safer, less invasive and more cost effective for the health-care system. Both studies have absolutely changed practice, and will continue to change practice worldwide.”

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97 (540.01808166504): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
98 (319.9577331543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
99 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
100 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
101 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
102 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
103 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
104 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
105 (261.06834411621): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
106 (!!!!! 19517.183303833): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
107 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
108 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
109 (497.10273742676): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800696 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800696 AND type='deeppockets_item' AND published='1' LIMIT 1
110 (!!!!! 480087.04185486): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
111 (85.830688476562): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
112 (422.95455932617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
113 (79.870223999023): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
114 (297.06954956055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
115 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
116 (198.8410949707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
117 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
118 (366.9261932373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
119 (117.06352233887): SELECT name FROM jos_deeppockets WHERE id=212
120 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=212
121 (448.94218444824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
122 (352.85949707031): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
123 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
124 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
125 (!!!!! 7505.8937072754): TRUNCATE TABLE jos_trademed_module
126 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
127 (803.94744873047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
128 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
129 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
130 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
131 (!!!!! 1024.9614715576): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
132 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
133 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
134 (34.093856811523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800696 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800696 AND type='deeppockets_item' AND published='1' LIMIT 1
135 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
136 (27.179718017578): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
137 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
138 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
139 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800696 AND published='1' LIMIT 1
140 (126.83868408203): select jos_twitters.link from jos_twitters where cat=10
141 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10
142 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10
143 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10
144 (288.96331787109): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
145 (!!!!! 1271.9631195068): insert into jos_banners_delta values (14615,'2025-04-29 16:31:50','18.218.226.136','view'),(14202,'2025-04-29 16:31:50','18.218.226.136','view'),(14203,'2025-04-29 16:31:50','18.218.226.136','view')