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New MRI Method Detects Alzheimer’s Earlier in People without Clinical Signs

By MedImaging International staff writers
Posted on 07 Mar 2024

The current approach to evaluating patients for Alzheimer’s disease involves combining medical history reviews, neurological exams, cognitive and functional assessments, and additional tests like brain imaging, spinal taps, and blood tests. However, there's a pressing need for more cost-effective and earlier detection methods to pave the way for new clinical trials and interventions. Now, new research has uncovered a connection between unusual blood levels of amyloid — a protein linked with Alzheimer’s — and subtle changes in brain microstructures observable on a specific type of MRI. These findings could offer a novel avenue for detecting Alzheimer’s earlier in asymptomatic individuals.

Researchers at University of Florida (Gainesville, FL, USA) conducted an analysis of 128 participants, both with and without dementia, who underwent positron emission tomography (PET) scans, a recognized tool for detecting amyloid plaques in the brain. The study revealed that even in cases where a PET scan failed to detect amyloid and the participant showed no dementia symptoms, there was still a link between abnormal blood amyloid levels and brain structural changes detected through an advanced imaging method known as diffusion MRI or "free-water" imaging. This research builds upon the team's previous work establishing free-water imaging as a reliable, noninvasive biomarker for Parkinson’s disease.

In this particular study, participants with amyloid-positive blood tests but amyloid-negative PET scans displayed brain alterations in diffusion MRI. These included reduced cortical volume and thickness, increased free-water across 24 brain regions, and diminished tissue microstructure in 66 areas. These findings suggest that free-water imaging is sensitive to early brain tissue and microstructural degeneration, even when PET scans show no signs of amyloid. The next phase of research aims to track these participants over time to observe if those with positive amyloid blood tests later develop positive amyloid PET scans. The focus will also be on understanding how free-water and blood amyloid levels change over time and correlate with symptoms, cognitive tests, and the eventual clinical diagnosis of Alzheimer’s disease.

“Previously people would say one of the earliest events you would see is amyloid positivity in the brain on a PET scan,” said senior author David Vaillancourt, Ph.D., a professor and chair of the UF College of Health & Human Performance’s department of applied physiology and kinesiology. “Our findings suggest there seem to be events occurring both in the blood and in the brain before you detect amyloid positivity in the brain.”

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86 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

95 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

96 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800495 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

98 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

99 (391.00646972656): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800495 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

100 (859.02214050293): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

101 (545.02487182617): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

102 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

103 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

104 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

105 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

106 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

107 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

108 (500.20217895508): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

109 (!!!!! 70028.066635132): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

110 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

111 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

112 (571.96617126465): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800495 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800495 AND type='deeppockets_item' AND published='1' LIMIT 1

113 (!!!!! 466791.86820984): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

114 (139.95170593262): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

115 (379.08554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

116 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

117 (376.93977355957): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

118 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

119 (216.96090698242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

120 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

121 (328.06396484375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

122 (196.93374633789): SELECT name FROM jos_deeppockets WHERE id=212

123 (138.99803161621): SELECT name FROM jos_deeppockets WHERE id=212

124 (468.01567077637): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

125 (493.04962158203): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

126 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

127 (109.19570922852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

128 (!!!!! 11668.920516968): TRUNCATE TABLE jos_trademed_module

129 (179.05235290527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800495 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

130 (533.10394287109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

131 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

133 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

134 (!!!!! 1502.0370483398): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

135 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

136 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

137 (65.803527832031): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800495 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800495 AND type='deeppockets_item' AND published='1' LIMIT 1

138 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

139 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

140 (43.153762817383): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

141 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

142 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800495 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800495 AND published='1' LIMIT 1

143 (162.12463378906): select jos_twitters.link from jos_twitters where cat=10

144 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

145 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

146 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

147 (374.07875061035): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

148 (!!!!! 1497.9839324951): insert into jos_banners_delta values (14615,'2025-04-29 16:16:26','3.17.61.107','view'),(14202,'2025-04-29 16:16:26','3.17.61.107','view'),(14203,'2025-04-29 16:16:26','3.17.61.107','view')

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