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Combined PET-MRI Scan Improves Treatment for Early Breast Cancer Patients

By MedImaging International staff writers
Posted on 21 Mar 2024

The typical diagnostic path for early breast cancer patients often involves mammography, ultrasound, and occasionally MRI scans. Now, a new study has found that using a combined scanning technique can enhance treatment decisions for nearly 30% of patients with early-stage breast cancer.

The study by researchers at San Raffaele Hospital (Milan, Italy) revealed that combining positron emission tomography with magnetic resonance imaging (PET-MRI) can detect early indications of tumor spread. This dual scanning technique allows doctors to identify patients who might benefit from a change in their treatment plans, such as the introduction of chemotherapy or an alternative surgical method. PET-MRI is a fairly recent innovation and is mostly applied in research settings. This study involved 205 patients undergoing treatment at San Raffaele Hospital from July 2020 to October 2023. Before proceeding with breast-conserving surgery to excise the tumor, each patient underwent a PET-MRI scan to check for cancer's spread within the breast, nearby areas, and throughout the body.

The findings led to a change in the treatment strategy for 57 of the 205 patients (27.8%). Among these, 18 received chemotherapy as an initial treatment, while 39 underwent varied surgical procedures, including mastectomy, the excision of additional lymph nodes, or operations on both breasts. Notably, in 12 of these 57 cases (21%), the additional tissue removed during surgery was found to be non-cancerous. The researchers are embarking on a subsequent study employing a modified PET-MRI technique aimed at detecting breast cancer cells stimulated by estrogen, offering potential advancements for diagnosing lobular breast cancer, which is typically more challenging to detect through standard mammograms or ultrasound scans.

“Our research suggests that for patients with early breast cancer, the addition of a PET-MRI scan to standard care could help us make more informed decisions about the best treatment pathway,” said Dr. Rosa Di Micco, a breast surgeon at IRCCS San Raffaele University and Research Hospital. “However, results of this technique are still affected by a high percentage of false positives and should therefore be confirmed by further testing.”

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89 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

92 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

93 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800618 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

95 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

96 (519.0372467041): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800618 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (653.98216247559): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (348.09112548828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (296.11587524414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

100 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

101 (138.0443572998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

102 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

103 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

104 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

105 (311.13624572754): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

106 (!!!!! 24950.02746582): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

107 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

108 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

109 (583.88710021973): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800618 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800618 AND type='deeppockets_item' AND published='1' LIMIT 1

110 (!!!!! 478459.11979675): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (102.99682617188): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (409.12628173828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (327.82554626465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (237.94174194336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (79.154968261719): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (307.79838562012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

119 (118.01719665527): SELECT name FROM jos_deeppockets WHERE id=212

120 (83.92333984375): SELECT name FROM jos_deeppockets WHERE id=212

121 (433.92181396484): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (482.08236694336): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (119.20928955078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

124 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

125 (!!!!! 10149.955749512): TRUNCATE TABLE jos_trademed_module

126 (144.00482177734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800618 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

127 (674.00932312012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

130 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

131 (!!!!! 1277.9235839844): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

132 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

133 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

134 (64.13459777832): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800618 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800618 AND type='deeppockets_item' AND published='1' LIMIT 1

135 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

136 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

137 (56.982040405273): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

138 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

139 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800618 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800618 AND published='1' LIMIT 1

140 (167.1314239502): select jos_twitters.link from jos_twitters where cat=10

141 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

142 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

143 (38.14697265625): select jos_linkedin.link from jos_linkedin where cat=10

144 (257.01522827148): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

145 (!!!!! 1548.0518341064): insert into jos_banners_delta values (14615,'2025-04-29 16:24:04','18.222.116.64','view'),(14202,'2025-04-29 16:24:04','18.222.116.64','view'),(14203,'2025-04-29 16:24:04','18.222.116.64','view')

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