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MRI ‘Probe’ Noninvasively Measures Placental Health

By MedImaging International staff writers
Posted on 08 Feb 2024

Image: A potential method uses MRI for noninvasively assessing placental health during pregnancy (Photo courtesy of 123RF)

The health of the placenta is essential for the well-being of a baby. However, currently, there isn't a direct method to evaluate how effectively this vital organ functions. Researchers have now demonstrated a noninvasive technique that has the potential to assess placental health during pregnancy. They achieved this by using advanced MRI methods to measure placental vascular reactivity, which refers to the placenta's ability to adjust its blood supply according to the fetus's needs.

In their study, researchers at Children’s Hospital Los Angeles (Los Angeles, CA, USA) focused on the placenta's crucial role in maintaining a stable oxygen environment for the developing fetus. The study involved 34 women with healthy pregnancies, whose gestational ages ranged from 22 to 32 weeks. Each participant underwent a seven-minute placental MRI examination. During the MRI, the women were instructed via video to perform yoga-like breathing exercises, including inhaling, holding their breath briefly, and then exhaling slowly. The researchers monitored the changing carbon dioxide levels of the mothers during these exercises. Employing a technique known as blood oxygen-dependent MRI, they observed the dilation and contraction of the placenta’s vascular system in response to these changing levels, without the use of external oxygen or contrast agents. The researchers aimed to assess the placenta's response to everyday changes and situations, rather than creating an artificial environment.

The findings of the study indicate that MRI can reliably measure placental vascular reactivity using these methods. This proof-of-concept study introduces a novel, noninvasive way to assess placental vascular health and function during pregnancy. The researchers also discovered that the placenta becomes more responsive as the fetus matures. Furthermore, they noted that irrespective of gestational age, a more reactive placenta correlated with a larger brain size in the baby. The research team’s next objective is to investigate the impact of placental dysfunction on brain development in babies with congenital heart disease. The ultimate aim is to enable clinicians to use placental vascular reactivity as a diagnostic tool for early detection of placental dysfunction, allowing for timely intervention.

“It’s exciting because this could serve as a potential biomarker, or functional probe, of placental health,” said Vidya Rajagopalan, Ph.D., an investigator in the Division of Cardiology at CHLA. “And it’s noninvasive. It doesn’t hurt mom; it doesn’t hurt baby.”

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91 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

92 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800198 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (597.00012207031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

94 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

95 (292.06275939941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800198 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (550.0316619873): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (431.06079101562): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

99 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

100 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

101 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

102 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

103 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

104 (341.17698669434): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

105 (!!!!! 279479.02679443): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

106 (340.93856811523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

107 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

108 (!!!!! 4481.7924499512): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800198 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800198 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 1999479.0554047): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (!!!!! 910145.9980011): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (106.0962677002): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

112 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

114 (80.108642578125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

116 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (644.92225646973): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

118 (292.06275939941): SELECT name FROM jos_deeppockets WHERE id=212

119 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=212

120 (593.18542480469): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

121 (496.14906311035): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (!!!!! 1399.040222168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

123 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

124 (!!!!! 7131.0997009277): TRUNCATE TABLE jos_trademed_module

125 (126.83868408203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800198 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

126 (606.06002807617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

127 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

129 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

130 (!!!!! 1579.9999237061): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

131 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

132 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

133 (524.99771118164): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800198 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800198 AND type='deeppockets_item' AND published='1' LIMIT 1

134 (558.13789367676): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

135 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

136 (46.968460083008): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

137 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

138 (62.227249145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800198 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800198 AND published='1' LIMIT 1

139 (57.93571472168): select jos_twitters.link from jos_twitters where cat=10

140 (44.107437133789): select jos_facebook.link from jos_facebook where cat=10

141 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

142 (39.815902709961): select jos_linkedin.link from jos_linkedin where cat=10

143 (302.07633972168): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

144 (!!!!! 1336.0977172852): insert into jos_banners_delta values (14615,'2025-04-29 17:46:51','3.144.97.63','view'),(14202,'2025-04-29 17:46:51','3.144.97.63','view'),(14203,'2025-04-29 17:46:51','3.144.97.63','view')

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