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Dual-Purpose Imaging Agents for PET and MRI Scanners Could Diagnose Neurodegenerative Diseases Earlier

By MedImaging International staff writers
Posted on 07 Feb 2024

Alzheimer's disease, a neurodegenerative condition, impairs brain function and cognitive abilities. It is classified along with Parkinson's disease, amyotrophic lateral sclerosis, and other disorders as an amyloid disease. Amyloids, comprising small groups of abnormally fibrous or misfolded proteins, typically serve no functional purpose in the body. A hallmark of Alzheimer’s is the formation of amyloid plaques, which are accumulations of beta-amyloid peptide aggregates. These peptides, short chains of amino acids, are precursors to proteins. Neuroinflammation and oxidative stress in the brain are also significant indicators of Alzheimer's. The diagnosis and treatment of such neurodegenerative diseases are challenging due to the blood-brain barrier, a semipermeable system of blood vessels and capillaries that controls the flow of ions, molecules, and cells between the blood and the brain. For imaging and therapeutic agents, composed of molecules or antibodies, to be effective, they must be able to pass through this barrier.

Currently, diagnosing Alzheimer’s disease with high accuracy is possible only post-mortem by identifying amyloid aggregates. This necessitates the development of diagnostic tools capable of detecting soluble beta-amyloid peptide aggregates and larger amyloid plaques in living patients. PET and MRI are two non-invasive imaging techniques frequently used clinically. Yet, there are no MRI contrast agents targeting amyloid aggregates, and existing FDA-approved PET imaging agents either fail to detect small-scale amyloid abnormalities or sometimes result in false-positive test results for Alzheimer’s. Thus, it is vital to create diagnostic tools targeting smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.

Now, a research team from Beckman Institute (Urbana, IL, USA) comprising a synthetic chemist, medical imaging expert, and neurologist are developing enhanced diagnostic tools and imaging agents for early-stage Alzheimer’s detection and other neurodegenerative diseases. Supported by a USD 3 million grant from the U.S. National Institute on Aging of the National Institutes of Health, the team aims to create and test multi-modal imaging agents for Alzheimer’s and related dementias over five years. These agents, designed to penetrate the blood-brain barrier and be compatible with both PET and MRI scanners, will facilitate earlier detection of neurodegenerative diseases and significantly aid in advancing therapeutic approaches.

Developing multi-modal tools for use in both PET and MRI will provide deeper insights into Alzheimer's risk, diagnosis, and progression. The researchers have already synthesized specialized molecules that can cross the blood-brain barrier and detect both small soluble beta-amyloid peptides and larger insoluble amyloids. They have also developed a copper-based PET imaging agent, which successfully visualized amyloid plaques in transgenic Alzheimer’s mice. Going forward, the team anticipates that these agents can be adapted for human use, enabling earlier detection of multiple markers of Alzheimer’s and other neurodegenerative diseases.

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83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

92 (40.769577026367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

93 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800178 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

95 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

96 (365.9725189209): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800178 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (542.16384887695): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (349.04479980469): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

100 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

101 (136.8522644043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

102 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

103 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

104 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

105 (332.83233642578): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

106 (!!!!! 22501.945495605): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

107 (154.97207641602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

108 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

109 (401.97372436523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800178 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800178 AND type='deeppockets_item' AND published='1' LIMIT 1

110 (!!!!! 493885.99395752): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (116.10984802246): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (311.85150146484): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (324.96452331543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (200.98686218262): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (255.10787963867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

119 (108.00361633301): SELECT name FROM jos_deeppockets WHERE id=212

120 (137.0906829834): SELECT name FROM jos_deeppockets WHERE id=212

121 (472.06878662109): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (345.94535827637): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

124 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

125 (!!!!! 5470.9911346436): TRUNCATE TABLE jos_trademed_module

126 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800178 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

127 (406.98051452637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

130 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

131 (!!!!! 1044.9886322021): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

132 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

133 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

134 (39.815902709961): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800178 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800178 AND type='deeppockets_item' AND published='1' LIMIT 1

135 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

136 (61.988830566406): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

137 (32.901763916016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

138 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

139 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800178 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800178 AND published='1' LIMIT 1

140 (123.02398681641): select jos_twitters.link from jos_twitters where cat=10

141 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

142 (27.179718017578): select jos_google_plus.link from jos_google_plus where cat=10

143 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10

144 (299.93057250977): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

145 (!!!!! 1295.0897216797): insert into jos_banners_delta values (14615,'2025-04-29 17:22:11','3.133.112.22','view'),(14202,'2025-04-29 17:22:11','3.133.112.22','view'),(14203,'2025-04-29 17:22:11','3.133.112.22','view')

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