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Breakthrough in Nanosized Contrast Agents to Enhance Magnetic Resonance Imaging

By MedImaging International staff writers
Posted on 06 Dec 2023

Image: Self-folding mechanism leads to enhanced contrast in MRI scans (Photo courtesy of Tokyo Tech)

Magnetic resonance imaging (MRI) plays a vital role in cancer diagnosis by capturing detailed images of soft tissues. For enhanced tumor visibility in MRI scans, doctors often administer contrast agents to patients. These agents impact the response of surrounding hydrogen ions to MRI's radiofrequency pulses. The aim of using contrast agents is to have them specifically accumulate in tumors, thereby heightening their visibility in the scans. However, traditional gadolinium (Gd)-chelate contrast agents have nearly reached their performance peak. One of the main challenges is achieving an optimal dose in the distribution of Gd-chelate in tumors, healthy tissue, and blood without excessive Gd doses.

In response, a collaborative study by a research team that included scientists from Tokyo Institute of Technology (Tokyo, Japan) has led to the development of a groundbreaking nano-contrast agent (NCA) using an innovative molecular design. This NCA utilizes Gd as the contrast agent within a "self-folding macromolecular drug carrier (SMDC)." The team integrated clinically approved Gd-containing chelates into a polymer chain comprising poly(ethylene glycol) methyl ether acrylate (PEGA) and benzyl acrylate (BZA). This polymer, featuring both hydrophilic and hydrophobic sections, spontaneously forms a small, capsule-like structure in water, positioning the hydrophobic segments internally and the hydrophilic ones externally.

This methodology allowed for the production of SMDC-Gds molecules under 10 nanometers in size. Experiments on mice with colon cancer demonstrated that these NCAs accumulated more effectively in tumors and were rapidly cleared from the bloodstream, thus enhancing MRI capabilities without toxic side effects. Furthermore, the team uncovered an additional benefit of SMDC-Gds over existing Gd-chelates. The optimal performance of Gd ions is achieved when their movement is restricted, ensuring a consistent and prolonged impact on neighboring hydrogen ions. The SMDC's core/shell structure creates a densely packed molecular environment that limits the rotation and internal motions of Gd ions, thereby resulting in a stronger contrast in MRI images. This will enable the use of alternative elements with safer profiles in patients as well as the environment in the future.

Beyond MRI applications, SMDC-Gds show promise in neutron capture therapy (NCT), an emerging targeted radiotherapy method. In NCT, Gds capture neutrons and emit high-energy radiation, destroying cancer cells in proximity. Experiments showed that NCT with repeated SMDC-Gd injections significantly reduced tumor growth, which can be attributed to the selective accumulation and deep penetration of SMDC-Gds in tumor tissues. The research highlights the potential of SMDCs not just for improved MRI diagnostics, but also as effective cancer treatment modalities and other medical applications.

"This study presents further possibilities for exploiting drug delivery using various therapeutic cargos, and we are currently investigating the development of such SMDC systems," said Associate Professor Yutaka Miura of Tokyo Tech who led the research team.

Related Links:
Tokyo Institute of Technology

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66 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

67 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

68 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE id=294799507 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799507 AND published='1' LIMIT 1

69 (34.093856811523): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (171.18453979492): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (179.05235290527): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (86.069107055664): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (33.140182495117): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (92.983245849609): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

105 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

106 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799507 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (43.869018554688): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799507 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

109 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

110 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799507 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (468.96934509277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799507 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (594.13909912109): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (430.10711669922): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

115 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

116 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

117 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

118 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

119 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

120 (309.94415283203): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 163929.93927002): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (!!!!! 11815.071105957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

123 (!!!!! 7893.0854797363): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

124 (!!!!! 7759.8094940186): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799507 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799507 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1904314.994812): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (127.07710266113): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (403.88107299805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (79.870223999023): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (354.05158996582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (320.9114074707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (!!!!! 2639.7705078125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (385.99967956543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 2058.9828491211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (!!!!! 1163.0058288574): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (702.85797119141): SELECT name FROM jos_deeppockets WHERE id=212

136 (288.00964355469): SELECT name FROM jos_deeppockets WHERE id=212

137 (!!!!! 1104.1164398193): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (!!!!! 1251.9359588623): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1163.0058288574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

140 (344.03800964355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

141 (!!!!! 56779.861450195): TRUNCATE TABLE jos_trademed_module

142 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799507 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (537.87231445312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799507 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 2330.0647735596): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (892.16232299805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (!!!!! 5310.05859375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

147 (715.01731872559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

148 (!!!!! 3553.8673400879): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (!!!!! 3383.8748931885): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

150 (785.82763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

151 (!!!!! 3315.9255981445): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799507 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799507 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (624.8950958252): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (744.10438537598): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (!!!!! 2221.8227386475): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (!!!!! 3191.9479370117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

156 (487.8044128418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799507 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799507 AND published='1' LIMIT 1

157 (!!!!! 2714.8723602295): select jos_twitters.link from jos_twitters where cat=10

158 (92.029571533203): select jos_facebook.link from jos_facebook where cat=10

159 (83.92333984375): select jos_google_plus.link from jos_google_plus where cat=10

160 (367.87986755371): select jos_linkedin.link from jos_linkedin where cat=10

161 (926.97143554688): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1103.8780212402): insert into jos_banners_delta values (14615,'2025-04-29 22:29:02','3.135.64.92','view'),(14202,'2025-04-29 22:29:02','3.135.64.92','view'),(14203,'2025-04-29 22:29:02','3.135.64.92','view')

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