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Advanced Assistive Technology Predicts Organ Deformation during Radiotherapy

By MedImaging International staff writers
Posted on 06 Oct 2023

Image: A new technology can accurately predict organ deformation during radiation therapy (Photo courtesy of 123RF)

Radiation therapy is a popular choice for treating cancer and other conditions, largely because it's minimally invasive, allowing patients to quickly resume their normal lives. One issue, though, is that radiation can affect nearby healthy organs, particularly when high radiation doses are administered to diseased tissues in motion. While regular movements like breathing are somewhat predictable, irregular movements caused by the organ's interactions with neighboring organs can be hard to predict. The ability to precisely anticipate how organs move during radiation treatment is crucial for improving the therapy's effectiveness. Now, a new technology can capture real-time cross-sectional images of the affected area and use them to create three-dimensional (3D) motion of organs. This enables accurate predictions of the deformation of the pancreas and other organs depending on their position related to the nearby organs during radiation therapy.

Researchers from the University of Tsukuba (Ibaraki, Japan) have developed an innovative technique to determine the 3D movement of organs based on their relative positions to neighboring organs. This is done by acquiring real-time cross-sectional (2D) images of the targeted area from three different orientations during radiation therapy. Additionally, the researchers have created a cross-section selection system for picking the most accurate 2D image for further analysis.

The research team validated their technique using publicly accessible MRI data from 20 cases to evaluate the pancreas's position. When using data from just one angle, the error in locating the pancreas was 5.11 mm. However, when data from all three angles was employed, this error shrank dramatically to just 2.13 mm. In some cases, the accuracy was even comparable to what would be achieved if 3D information had been gathered beforehand. These findings could pave the way for radiation therapy protocols designed to minimize radiation exposure to nearby healthy organs, resulting in safer radiation therapy.

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82 (30.040740966797): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

83 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

98 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

99 (90.837478637695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798866 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

100 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798866 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

101 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

102 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

103 (670.9098815918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798866 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

104 (373.84033203125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798866 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

105 (347.85270690918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798864 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

106 (514.03045654297): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

107 (295.87745666504): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

108 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

109 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

110 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

111 (34.809112548828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

112 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

113 (34.809112548828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

114 (151.8726348877): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

115 (!!!!! 17318.964004517): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

116 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

117 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

118 (366.9261932373): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798866 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798866 AND type='deeppockets_item' AND published='1' LIMIT 1

119 (!!!!! 423997.16377258): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

120 (91.075897216797): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

121 (348.09112548828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

122 (104.18891906738): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

123 (214.81513977051): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

124 (69.856643676758): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

125 (130.17654418945): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

126 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

127 (257.01522827148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (220.06034851074): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (124.93133544922): SELECT name FROM jos_deeppockets WHERE id=212

130 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=212

131 (464.91622924805): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

132 (444.88906860352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

133 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

134 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

135 (!!!!! 8857.0117950439): TRUNCATE TABLE jos_trademed_module

136 (119.92454528809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798866 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

137 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798866 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

138 (838.9949798584): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

141 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

142 (!!!!! 1064.0621185303): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

143 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

144 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

145 (36.954879760742): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798866 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798866 AND type='deeppockets_item' AND published='1' LIMIT 1

146 (65.088272094727): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

147 (50.067901611328): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

148 (38.14697265625): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

149 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

150 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798866 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798866 AND published='1' LIMIT 1

151 (159.02519226074): select jos_twitters.link from jos_twitters where cat=10

152 (29.802322387695): select jos_facebook.link from jos_facebook where cat=10

153 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

154 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

155 (398.15902709961): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

156 (!!!!! 1212.1200561523): insert into jos_banners_delta values (14615,'2025-04-29 22:54:45','3.135.237.153','view'),(14202,'2025-04-29 22:54:45','3.135.237.153','view'),(14203,'2025-04-29 22:54:45','3.135.237.153','view')

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