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Total-Body PET Creates New Patient Care Opportunities

By MedImaging International staff writers
Posted on 18 Jan 2018

Image: The EXPLORER total-body PET/CT scanner (Photo courtesy of Martin Judenhofer /UCD).

A first-generation total-body positron emission tomography/computed tomography (PET/CT) scanner could revolutionize the understanding and treatment of disease, claims a new study.

Under development at the University of California Davis (UCD, USA), in collaboration with United Imaging Healthcare (Shanghai, China), the prototype total-body PET/CT scanner, called EXPLORER, will offer the ability to detect focal pathologies throughout the whole body at once, including cancer, infection, and inflammation, and at considerably lower levels of disease activity than currently possible. It will also reduce the time taken to scan the whole body by at least a factor of 10, leading to scan times that could be less than one minute.

By covering the entire body at once, sensitivity is increased by a factor of ~40 for total-body imaging, or a factor of ~4-5 for imaging a single organ such as the brain or heart. Significant improvements in timing resolution could lead to even further sensitivity gains. According to the researchers, the combination with total-body PET could produce overall sensitivity gains of more than two orders of magnitude, when compared to existing state-of-the-art systems. The study was published in the January 2018 issue of the Journal of Nuclear Medicine (JNM).

“One total-body PET scanner could take on the work load of three-to-four conventional PET scanners, and being able to receive imaging biomarkers from more distant distribution centers will minimize the need for costly in-house biomarker production,” said Terry Jones, DSc, clinical professor of diagnostic radiology at UCD. “As the impact of high-sensitivity, total-body PET scanning becomes apparent, this will provide a major stimulus to physicists, chemists, and engineers to develop lower-cost detectors for total-body surveillance.”

PET is a nuclear medicine imaging technique that produces a 3D image of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide tracer. Tracer concentrations within the body are then constructed in 3D by computer analysis. In modern PET-CT scanners, 3D imaging is often accomplished with the aid of a CT X-ray scan performed on the patient during the same session, in the same machine.

Related Links:
University of California Davis
United Imaging Healthcare

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69 (34.093856811523): select jos_facebook.link from jos_facebook where cat=10

70 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

71 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

72 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE id=294772214 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294772214 AND published='1' LIMIT 1

73 (49.114227294922): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

74 (306.84471130371): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (308.03680419922): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (39.815902709961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (61.03515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (36.954879760742): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

109 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

110 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

113 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

114 (60.796737670898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294772214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (474.92980957031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294772214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (634.90867614746): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (336.1701965332): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

119 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

120 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

121 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

122 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

123 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

124 (278.94973754883): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 17591.953277588): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

127 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

128 (557.89947509766): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772214 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772214 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 468585.96801758): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (67.949295043945): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (316.85829162598): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (236.03439331055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (179.05235290527): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (124.93133544922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (265.12145996094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (306.12945556641): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (106.0962677002): SELECT name FROM jos_deeppockets WHERE id=215

140 (67.949295043945): SELECT name FROM jos_deeppockets WHERE id=215

141 (414.13307189941): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (330.92498779297): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

144 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

145 (!!!!! 17606.019973755): TRUNCATE TABLE jos_trademed_module

146 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (851.15432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

151 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

152 (!!!!! 1475.0957489014): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

154 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

155 (100.13580322266): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772214 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772214 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

157 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

158 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

160 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772214 AND published='1' LIMIT 1

161 (105.85784912109): select jos_twitters.link from jos_twitters where cat=10

162 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10

163 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

164 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

165 (252.00843811035): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1199.0070343018): insert into jos_banners_delta values (14615,'2025-04-29 22:06:44','3.143.213.242','view'),(14202,'2025-04-29 22:06:44','3.143.213.242','view'),(14203,'2025-04-29 22:06:44','3.143.213.242','view')

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