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AI Assistance Improves Breast-Cancer Screening by Reducing False Positives

By MedImaging International staff writers
Posted on 11 Apr 2024

Image: AI-assisted breast-cancer screening may reduce unnecessary testing (Photo courtesy of WUSTL)

Radiologists typically detect one case of cancer for every 200 mammograms reviewed. However, these evaluations often result in false positives, leading to unnecessary patient recalls for additional testing, which not only causes patient anxiety but also consumes valuable medical resources. Now, a new study has shown how artificial intelligence (AI) can improve the accuracy of breast cancer screening by minimizing these false positives without missing true positives.

The study by researchers at Washington University School of Medicine in St. Louis (St. Louis, MO, USA) and Whiterabbit.ai (Santa Clara, CA, USA) builds on their previous collaboration for the development of an AI algorithm to help radiologists assess breast density on mammograms for identifying people who stand to benefit from additional or alternative screening. That algorithm is marketed by Whiterabbit.ai as WRDensity after receiving clearance from the Food and Drug Administration (FDA) in 2020.

In the current study, the team developed an algorithm to identify normal mammograms with extremely high sensitivity. They went on to run a simulation on patient data to see what would have happened if all of the very low-risk mammograms were taken off the radiologists’ plates, allowing the doctors to focus on the more questionable scans. The results of this simulation indicated that such an approach would reduce the number of unnecessary patient callbacks for additional testing, yet maintain the same rate of cancer detection.

“At the end of the day, we believe in a world where the doctor is the superhero who finds cancer and helps patients navigate their journey ahead,” said Jason Su, co-founder and chief technology officer at Whiterabbit.ai. “The way AI systems can help is by being in a supporting role. By accurately assessing the negatives, it can help remove the hay from the haystack so doctors can find the needle more easily. This study demonstrates that AI can potentially be highly accurate in identifying negative exams. More importantly, the results showed that automating the detection of negatives may also lead to a tremendous benefit in the reduction of false positives without changing the cancer detection rate.”

Related Links:
WUSTL
Whiterabbit.ai

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90 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

92 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

93 (118.01719665527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800860 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

95 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

96 (791.78810119629): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800860 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (634.90867614746): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800851 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (844.00177001953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (776.05247497559): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

101 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

102 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

103 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

104 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

105 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

106 (460.14785766602): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 29349.088668823): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (140.19012451172): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

109 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

110 (620.84197998047): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800860 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800860 AND type='deeppockets_item' AND published='1' LIMIT 1

111 (!!!!! 536464.92958069): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (122.0703125): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (392.91381835938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (165.93933105469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

115 (385.04600524902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (171.18453979492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

117 (343.08433532715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (121.8318939209): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

119 (380.03921508789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (176.19132995605): SELECT name FROM jos_deeppockets WHERE id=215

121 (168.0850982666): SELECT name FROM jos_deeppockets WHERE id=215

122 (711.91787719727): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (568.15147399902): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

125 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

126 (!!!!! 12154.102325439): TRUNCATE TABLE jos_trademed_module

127 (144.95849609375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800860 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (783.92028808594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

131 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

132 (!!!!! 1745.9392547607): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

134 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

135 (61.03515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800860 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800860 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

137 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

138 (43.869018554688): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (235.08071899414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

140 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800860 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800860 AND published='1' LIMIT 1

141 (223.15979003906): select jos_twitters.link from jos_twitters where cat=10

142 (46.968460083008): select jos_facebook.link from jos_facebook where cat=10

143 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

144 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

145 (427.9613494873): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 2022.9816436768): insert into jos_banners_delta values (14615,'2025-04-29 15:59:04','18.191.212.175','view'),(14202,'2025-04-29 15:59:04','18.191.212.175','view'),(14203,'2025-04-29 15:59:04','18.191.212.175','view')

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