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Breakthrough AI Digital Biomarker Tool Rapidly Identifies Lung Fibrosis on CT Scans

By MedImaging International staff writers
Posted on 19 Jan 2024

Image: The Fibresolve digital biomarker solution uses AI to guide safe, non-invasive diagnosis of lung fibrosis (Photo courtesy of IMVARIA)

Lung fibrosis, a critical group of diseases impacting hundreds of thousands annually, includes idiopathic pulmonary fibrosis (IPF) which is particularly known for its severity. Current treatments for IPF are not only costly but can also be harmful if administered to unsuitable patients. Typically, there's a delay of about two and a half years in diagnosing this condition following the appearance of the first symptoms. This delay is critical as severe lung damage or even death could occur within one to two years from the onset of lung fibrosis. To address this challenge, a groundbreaking digital biomarker solution uses artificial intelligence (AI) to guide safe, non-invasive diagnosis of lung fibrosis with a focus on IPF.

IMVARIA Inc.’s (Berkeley, CA, USA) Fibresolve is a software-only device that processes and interprets lung computed tomography (CT) imaging data. Its primary purpose is to aid in diagnosing ILD by offering a diagnostic subtype classification for suspected cases. Before considering more invasive diagnostic methods, data from patients with suspected ILD is run on Fibresolve which utilizes IMVARIA’s AI algorithm to analyze the data and provide valuable non-invasive adjunct information for classification. This tool aids clinicians in quickly determining an accurate diagnosis, enabling them to administer appropriate treatments sooner. Moreover, Fibresolve offers a cost-effective alternative, potentially saving thousands of dollars per test and benefiting the overall health system financially.

Fibresolve’s results are designed for use by clinicians specializing in lung disease, particularly those managing ILD patients. These results should be interpreted in conjunction with the patient's clinical history, symptoms, other diagnostic tests, and the clinician's expert judgment. The U.S. Food and Drug Administration (FDA) has granted marketing authorization for Fibresolve, making it the first FDA-approved diagnostic tool for lung fibrosis.

“Fibresolve serves as an adjunct to clinicians in assessing patients with suspected lung fibrosis to provide a diagnostic subtype classification, potentially facilitating proper treatments at an earlier stage of the disease process,” said Joshua Reicher, MD, Co-founder and CEO of IMVARIA. “The FDA’s authorization of Fibresolve marks a significant milestone, not only for lung fibrosis patients but also for the advancement of AI-based healthcare technologies.”

“For people living with the rapidly deteriorating symptoms of this rare, yet deadly disease, the FDA authorization of Fibresolve offers real hope, while giving doctors who treat these patients a new, powerful tool that is designed to save lives and reduce suffering at an exponential rate that only AI can deliver,” added Michael Muelly, MD, Co-founder and CTO of IMVARIA. “This truly is a major step forward in advancing digital healthcare through the use of AI in the hands of medical doctors.”

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69 (40.769577026367): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (!!!!! 2459.0492248535): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (338.07754516602): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (52.213668823242): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (709.05685424805): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (79.870223999023): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (212.19253540039): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (61.03515625): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (57.93571472168): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (153.77998352051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

105 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

106 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (113.01040649414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (635.14709472656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

109 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

110 (49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (560.99891662598): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 5204.9160003662): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1863.0027770996): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 4002.0942687988): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

115 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

116 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

117 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

118 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

119 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

120 (401.97372436523): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 113971.94862366): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (!!!!! 1800.0602722168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

123 (188.11225891113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

124 (!!!!! 4114.1510009766): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799965 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799965 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1316353.0826569): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (224.82872009277): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (212.9077911377): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (97.036361694336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (103.95050048828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (74.148178100586): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (65.088272094727): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (630.14030456543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (!!!!! 1523.9715576172): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (308.03680419922): SELECT name FROM jos_deeppockets WHERE id=215

136 (236.98806762695): SELECT name FROM jos_deeppockets WHERE id=215

137 (607.96737670898): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (916.0041809082): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (390.05279541016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

140 (!!!!! 2428.0548095703): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

141 (!!!!! 19780.874252319): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 1705.8849334717): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (216.00723266602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 4550.9338378906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (126.83868408203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

147 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

148 (!!!!! 1193.0465698242): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (200.98686218262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

150 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

151 (936.03134155273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799965 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799965 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (65.088272094727): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (44.107437133789): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (355.95893859863): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (!!!!! 2811.9087219238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

156 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799965 AND published='1' LIMIT 1

157 (105.14259338379): select jos_twitters.link from jos_twitters where cat=10

158 (118.01719665527): select jos_facebook.link from jos_facebook where cat=10

159 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

160 (!!!!! 3319.9787139893): select jos_linkedin.link from jos_linkedin where cat=10

161 (309.94415283203): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 7210.0162506104): insert into jos_banners_delta values (14615,'2025-04-29 21:11:13','18.119.99.38','view'),(14202,'2025-04-29 21:11:13','18.119.99.38','view'),(14203,'2025-04-29 21:11:13','18.119.99.38','view')

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