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PET Heart Scans Can Identify Individuals at Risk of Developing Parkinson’s Disease

By MedImaging International staff writers
Posted on 09 Nov 2023

Scientists have discovered that positron emission tomography (PET) scans of the heart might be able to identify those at risk of developing Parkinson’s disease or Lewy body dementia. Both these conditions are associated with abnormal accumulations of alpha-synuclein protein in the brain, and the ability to detect early changes could improve our understanding and potential intervention for these diseases.

In a small study, researchers at the National Institutes of Health (Bethesda, MD, USA) conducted PET scans on 34 individuals who were considered at risk for Parkinson’s due to various factors. They were looking at the heart to measure the activity of norepinephrine, a messenger in the nervous system that is linked to dopamine—a chemical that is known to be at low levels in Parkinson's patients. Previous studies had already indicated that those suffering from Lewy body conditions experience a marked reduction of norepinephrine in the heart.

The latest study revealed that at-risk individuals with lower levels of 18F-dopamine-derived radioactivity in the heart were more likely to be diagnosed with Parkinson’s or Lewy body dementia over time. The participants underwent heart PET scans using a radioactive tracer at 18-month intervals for a maximum of about 7.5 years, or until they were diagnosed. Initially, out of nine people with lower levels of cardiac radioactivity from the dopamine tracer, eight went on to develop Parkinson’s or Lewy body dementia. In contrast, among those who showed normal levels of radioactivity on their first scan, only one later developed these conditions. Notably, all nine individuals who eventually were diagnosed with a Lewy body disease had displayed low radioactivity at or before their diagnosis.

The findings suggest that Parkinson’s and Lewy body dementia might impact the nervous system that controls automatic body functions, including the heart rate and blood pressure. The aggregation of synuclein, a process common to both disorders, also occurs in the nerves leading to other organs. By using PET scans to recognize those who might be in the preclinical stages of Lewy body diseases, there may be opportunities to explore preventive strategies that could involve lifestyle changes, dietary supplements, or other medical therapies.

“Imagine the scans are frames of a movie,” said David S. Goldstein, M.D., Ph.D., NINDS Principal Investigator. “The frame at 8 minutes during the first evaluation is already enough to identify the people who are likely to go on to develop a central Lewy body disease years later.”

Related Links:
National Institutes of Health

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		LIMIT 1
48
(45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
49
(83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
50
(56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
51
(77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
52
(45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
53
(257.01522827148): SELECT name FROM jos_deeppockets WHERE id=294799235 LIMIT 1
54
(292.06275939941): SELECT name FROM jos_deeppockets_archive WHERE id=294799235 LIMIT 1
55
(41.007995605469): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'
56
(52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294799235
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
57
(382.90023803711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294799235
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
58
(!!!!! 1186.1324310303): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
59
(60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
60
(123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
61
(53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
62
(82.969665527344): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 1
63
(495.19538879395): SELECT fid FROM jos_deeppockets WHERE id=294799235 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799235 AND published='1'  LIMIT 1
64
(46.014785766602): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
65
(37.193298339844): select jos_twitters.link from jos_twitters where cat=10
66
(30.040740966797): select jos_facebook.link from jos_facebook where cat=10
67
(29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10
68
(28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10
69
(62.942504882812): SELECT fid FROM jos_deeppockets WHERE id=294799235 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799235 AND published='1'  LIMIT 1
70
(42.915344238281): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
71
(354.05158996582): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294799235
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
72
(303.03001403809): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
73
(41.007995605469): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
74
(72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1
75
(43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1
76
(46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1
77
(39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
78
(28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
79
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
80
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
81
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
82
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
83
(31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
84
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
85
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
86
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
87
(61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1
88
(47.206878662109): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294799235
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
89
(29.802322387695): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
90
(33.140182495117): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
91
(45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1
92
(30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
93
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
94
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
95
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
96
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
97
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
98
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
99
(31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
100
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
101
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
102
(29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
103
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
104
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
105
(69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
106
(44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
107
(54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294799235
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
108
(48.160552978516): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294799235
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
109
(90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
110
(44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
111
(46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294799235
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
112
(475.16822814941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294799235
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
113
(634.19342041016): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
114
(409.84153747559): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
115
(90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
116
(54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
117
(121.8318939209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
118
(50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
119
(80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
120
(49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
121
(500.91743469238): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
122
(!!!!! 20988.941192627): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7
123
(102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
124
(53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
125
(394.10591125488): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799235 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799235 AND type='deeppockets_item' AND published='1'  LIMIT 1
126
(!!!!! 412231.92214966): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
127
(72.002410888672): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
128
(38.14697265625): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
129
(29.802322387695): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
130
(61.03515625): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
131
(30.040740966797): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
132
(36.954879760742): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
133
(28.133392333984): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
134
(341.17698669434): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294799235
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
135
(284.91020202637): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294799235
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
136
(46.968460083008): SELECT name FROM jos_deeppockets WHERE id=215
137
(26.941299438477): SELECT name FROM jos_deeppockets WHERE id=215
138
(480.89027404785): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
139
(344.03800964355): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
140
(115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
141
(51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
142
(!!!!! 6149.0535736084): TRUNCATE TABLE jos_trademed_module
143
(670.19462585449): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294799235
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
144
(177.14500427246): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294799235
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
145
(581.97975158691): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294799235
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146
(102.99682617188): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294799235
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147
(!!!!! 3226.9954681396): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
148
(207.90100097656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
149
(!!!!! 1490.1161193848): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6
150
(292.06275939941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
151
(51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
152
(122.0703125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799235 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799235 AND type='deeppockets_item' AND published='1'  LIMIT 1
153
(30.994415283203): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
154
(29.802322387695): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
155
(277.04238891602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
156
(365.01884460449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
157
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799235 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799235 AND published='1'
		LIMIT 1
158
(337.12387084961): select jos_twitters.link from jos_twitters where cat=10
159
(32.901763916016): select jos_facebook.link from jos_facebook where cat=10
160
(29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10
161
(29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10
162
(293.97010803223): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)
163
(!!!!! 1239.0613555908): insert into jos_banners_delta values (14615,'2025-04-29 21:30:18','52.14.238.102','view'),(14202,'2025-04-29 21:30:18','52.14.238.102','view'),(14203,'2025-04-29 21:30:18','52.14.238.102','view')