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Cellphone-Based Microscope Helps Treat River Blindness

By MedImaging International staff writers
Posted on 21 Nov 2017

A smartphone-connected microscope uses video technology to automatically detect and quantify infection by parasitic worms in a drop of blood, according to a new study.

Developed at the University of California (UC, Berkeley, USA), LoaScope technology is a field-friendly diagnostic tool that turns the camera of a mobile phone or tablet computer into a high-quality light microscope. The technology has applications that incude infectious disease diagnosis, ocean microorganism surveys, eye disease detection diagnosis, and classroom education. For the study, the LoaScope was used to identify persons with Loa loa microfilariae in their peripheral blood with a density greater than 20,000 microfilariae per milliliter of blood.

The quantification was necessary to identify persons if patients suffering from river blindness are also infected with Loa loa before receiving treatment. River blindness is caused by another parasitic worm, Onchocerca volvulus, which is transmitted to humans through bites of infected black flies; left untreated, infections in the eye can lead to blindness. The medication to treat the infection, ivermectin, can be fatal when the patient also has high blood levels of Loa loa. From August through October 2015, 16,259 persons five years of age or older were tested for Loa loa.

The results showed that among study participants who underwent testing, 95.5% received ivermectin, 2.1% were excluded from ivermectin distribution because of an L. loa microfilarial density above the risk threshold, and 2.4% were excluded because of pregnancy or illness. No serious adverse events were observed, and non-serious adverse events were recorded in 934 participants, most of whom (67.5%) had no detectable L. loa microfilariae. The study was published on November 8, 2017, in the New England Journal of Medicine (NEJM).

“This is not just a step forward for efforts to eliminate river blindness, but it is a demonstration that mobile microscopy, based on a mobile phone, can safely and effectively expand access to healthcare,” said study co-author bioengineering professor Daniel Fletcher, PhD. “This work sets the stage for expanding the use of mobile microscopy to improve diagnosis and treatment of other diseases, both in low-resource areas and eventually back in the United States.”

Ivermectin is effective against many different types of parasites, such as head lice, scabies, river blindness, strongyloidiasis, and lymphatic filariasis, among others. It has an added bonus of helping keep malaria-carrying mosquito populations at bay. Discovered in 1975, Ivermectin works by causing an increase in the permeability of the cell membrane, resulting in paralysis and death of the parasite.

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64 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

65 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

66 (105.85784912109): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

67 (494.00329589844): SELECT fid FROM jos_deeppockets WHERE id=294771570 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294771570 AND published='1' LIMIT 1

68 (43.869018554688): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

69 (39.100646972656): select jos_twitters.link from jos_twitters where cat=10

70 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

71 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

72 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

73 (32.901763916016): SELECT fid FROM jos_deeppockets WHERE id=294771570 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294771570 AND published='1' LIMIT 1

74 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

75 (298.97689819336): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (221.01402282715): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

95 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

110 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

111 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

114 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

115 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294771570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (442.9817199707): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294771570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (548.8395690918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (319.9577331543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

120 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

121 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

122 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

123 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

124 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

125 (312.80517578125): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 28750.18119812): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

128 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

129 (407.93418884277): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771570 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771570 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 403915.8821106): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (69.141387939453): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

134 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

136 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

138 (511.16943359375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (430.82237243652): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=215

141 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=215

142 (579.833984375): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (545.02487182617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (167.8466796875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

145 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

146 (!!!!! 10414.123535156): TRUNCATE TABLE jos_trademed_module

147 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (54.836273193359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771570 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (762.939453125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

152 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

153 (!!!!! 1247.8828430176): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

155 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

156 (44.107437133789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771570 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771570 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

158 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

159 (37.908554077148): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

161 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771570 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771570 AND published='1' LIMIT 1

162 (47.922134399414): select jos_twitters.link from jos_twitters where cat=10

163 (39.100646972656): select jos_facebook.link from jos_facebook where cat=10

164 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

165 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

166 (318.05038452148): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

167 (!!!!! 1423.8357543945): insert into jos_banners_delta values (14615,'2025-04-29 21:22:23','52.15.143.11','view'),(14202,'2025-04-29 21:22:23','52.15.143.11','view'),(14203,'2025-04-29 21:22:23','52.15.143.11','view')

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