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Alpha Radiation Brachytherapy Destroys Solid Tumors

By MedImaging International staff writers
Posted on 03 Sep 2018

A high-precision, short-range cancer radiotherapy (RT) system releases α particles when radioactive substances decay, effectively killing solid tumor cancer cells while sparing surrounding healthy tissues.

Under development by Alpha Tau Medical (Tel Aviv, Israel), Alpha DaRT (Diffusing Alpha-emitters Radiation Therapy) is based on intratumoral insertion of a radioactive seed (similar in size and shape to fiducial markers) that contains Radium-224 atoms embedded below its surface, with a half-life of 3.7 days. In the process of decay, the Radium atoms release short-lived Alpha-emitting atoms into the tumor, which are known to be highly destructive to all cancerous cells, regardless of their cell cycle stage or level of oxygenation.

When the Radium-224 decays, its short-lived daughters are released from the seed, dispersing into the tumor and emitting high-energy alpha particles that directly damage cell DNA, creating complex double-strand breaks lethal to the tumor. By diffusion and convection, the Alpha-emitting atoms disperse to a therapeutically significant range of several millimeters, delivering a high dose of radiation inside the tumor. Since alpha particles are so potent, the total activity on each seed is very low, and the overall exposure to gamma radiation of surrounding tissues is negligible.

The Alpha DaRT seeds are delivered via disposable and easy to-use applicators inserted through ultra-minimally invasive procedures. Benefits of the brachytherapy treatment included highly potent and conformal delivery; proven efficacy for all solid tumors tested; single-session treatment; effective RT regardless of tumor oxygenation level; quick clinical outcomes; combination with other therapies or re-application; and safety for both patient and clinician, without the need for shielding equipment.

“In 1898 Marie Curie discovered radium, a substance that emits alpha particles radiation, and Curie even then believed that this radiation can aid in cancer healing. Alpha Particles are heavy particles that hit the tumor cells but do not pass into the normal tissue surrounding the tumor or the systemic blood vessels in the rest of the body,” said Uzi Sofer, CEO of Alpha Tau Medical. “Alpha particles can travel only about 1-2 microns, millions of a centimeter, in tissue; that is why there are no side effects.”

Alpha particles consist of two protons and two neutrons bound together into a particle identical to a helium-4 nuclei; thus, like helium nuclei, they have a net spin of zero. Due to the mechanism of their production in standard alpha radioactive decay, α particles generally have a kinetic energy of about 5 MeV, a velocity in the vicinity of 5% the speed of light, and a low penetration depth. They are able to be stopped by a few centimeters of air.

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64 (!!!!! 1752.8533935547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

65 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

66 (288.00964355469): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

67 (399.11270141602): SELECT fid FROM jos_deeppockets WHERE id=294774701 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774701 AND published='1' LIMIT 1

68 (178.09867858887): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

69 (39.815902709961): select jos_twitters.link from jos_twitters where cat=10

70 (32.186508178711): select jos_facebook.link from jos_facebook where cat=10

71 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

72 (72.002410888672): select jos_linkedin.link from jos_linkedin where cat=10

73 (91.075897216797): SELECT fid FROM jos_deeppockets WHERE id=294774701 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774701 AND published='1' LIMIT 1

74 (171.89979553223): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

75 (259.8762512207): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (235.79597473145): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (56.982040405273): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 1438.1408691406): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (27.179718017578): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (63.896179199219): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

95 (501.15585327148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (366.2109375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

110 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

111 (149.96528625488): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774701 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774701 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (809.90791320801): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

114 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

115 (78.916549682617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774701 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (393.86749267578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774701 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (548.8395690918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (318.05038452148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

120 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

121 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

122 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

123 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

124 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

125 (277.99606323242): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 43087.005615234): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (217.91458129883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

128 (159.02519226074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

129 (!!!!! 2804.0409088135): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774701 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774701 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 761132.95555115): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (98.943710327148): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

134 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

136 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

138 (616.07360839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (415.08674621582): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=215

141 (27.894973754883): SELECT name FROM jos_deeppockets WHERE id=215

142 (577.92663574219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (427.0076751709): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

145 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

146 (!!!!! 11693.954467773): TRUNCATE TABLE jos_trademed_module

147 (175.95291137695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774701 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774701 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (623.94142150879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

152 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

153 (!!!!! 1612.1864318848): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (104.18891906738): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

155 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

156 (107.0499420166): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774701 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774701 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

158 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

159 (60.081481933594): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

161 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774701 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774701 AND published='1' LIMIT 1

162 (51.021575927734): select jos_twitters.link from jos_twitters where cat=10

163 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

164 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

165 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

166 (276.08871459961): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

167 (!!!!! 1182.0793151855): insert into jos_banners_delta values (14615,'2025-04-29 22:06:55','3.143.213.242','view'),(14202,'2025-04-29 22:06:55','3.143.213.242','view'),(14203,'2025-04-29 22:06:55','3.143.213.242','view')

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