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AI Tool Measures Lung Nodules with High Accuracy

By MedImaging International staff writers
Posted on 12 Apr 2021

Image: NineMeasures automaticall measure a lung nodules axes (Photo courtesy of Nines)

An innovative lung nodule measurement tool built with artificial intelligence (AI) can help accelerate diagnosis of certain respiratory diseases.

The Nines (Palo Alto, CA, USA) NinesMeasure semi-automatic tool is intended for use by trained radiologists to aid in the analysis and review of adult thoracic computerized tomography (CT) images. NinesMeasure provides quantitative information on pulmonary nodule size on a single study by providing both long and short axis diameter measurements in the axial plane. By doing so, it automates a time consuming, tedious process, as each nodule has to be measured carefully to determine changes in size over time.

Based on the analysis of digital imaging and communications in medicine (DICOM) data and input from a radiologist that indicates the location of the pulmonary nodule, the device uses AI algorithms to perform the measurements automatically. It can also be used monitor lung nodule size progression and address inter-study consistency spanning a patient's full treatment program. NinesMeasure is strictly limited to analysis of imaging data; in does not replace patient evaluation, nor should it be relied upon to make or confirm a diagnosis.

“In general, radiology is tech-forward in its use of digital imaging, but innovation can make it better,” said David Stavens, PhD, co-founder and CEO of Nines. “Nines has been leading the way by pairing two seemingly disparate groups, skilled radiologists and brilliant engineers, to transform the practice of radiology to be more accessible and more efficient, delivering faster results for quality patient care. That is worth innovating.”

Current lung nodule classification relies on nodule size, a factor that is of limited use for sub-centimeter nodules, or on volume doubling time, a variable that requires follow-up CT exams. As a result, very small lung nodules, with solid components of less than 8 mm in diameter, and therefore below the Lung-RADS 4A risk-stratification threshold, are very difficult to classify, and they are often given a "wait and see" management plan.

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71 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

72 (36.001205444336): SELECT fid FROM jos_deeppockets WHERE id=294787824 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294787824 AND published='1' LIMIT 1

73 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

74 (462.05520629883): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (!!!!! 2598.0472564697): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (91.075897216797): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (66.995620727539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (44.107437133789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (34.809112548828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 3974.1992950439): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (102.04315185547): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (!!!!! 3656.8641662598): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (!!!!! 3477.8118133545): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

109 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

110 (60.796737670898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294787824 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (534.0576171875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294787824 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

113 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

114 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294787824 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (468.96934509277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294787824 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (619.88830566406): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (!!!!! 2581.1195373535): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

119 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

120 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

121 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

122 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

123 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

124 (272.03559875488): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 43756.008148193): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (204.08630371094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

127 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

128 (720.02410888672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294787824 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294787824 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 1766182.8994751): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (!!!!! 2156219.0055847): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (!!!!! 12160.062789917): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (!!!!! 12259.006500244): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (!!!!! 11597.871780396): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (!!!!! 5929.9468994141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (!!!!! 7786.9892120361): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (277.04238891602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (781.05926513672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (573.87351989746): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (562.19100952148): SELECT name FROM jos_deeppockets WHERE id=215

140 (!!!!! 1065.0157928467): SELECT name FROM jos_deeppockets WHERE id=215

141 (709.05685424805): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (!!!!! 1728.0578613281): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (!!!!! 1167.0589447021): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

144 (!!!!! 1654.1481018066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

145 (!!!!! 4060.0299835205): TRUNCATE TABLE jos_trademed_module

146 (!!!!! 2354.8603057861): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294787824 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (566.00570678711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294787824 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (375.03242492676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

151 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

152 (!!!!! 1044.0349578857): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

154 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

155 (442.9817199707): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294787824 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294787824 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

157 (27.894973754883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

158 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

160 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294787824 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294787824 AND published='1' LIMIT 1

161 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

162 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10

163 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

164 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

165 (280.85708618164): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 8249.9980926514): insert into jos_banners_delta values (14615,'2025-04-29 21:05:51','18.116.118.216','view'),(14202,'2025-04-29 21:05:51','18.116.118.216','view'),(14203,'2025-04-29 21:05:51','18.116.118.216','view')

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