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New Whole-Body Imaging Technology Makes It Possible to View Inflammation on MRI Scan

By MedImaging International staff writers
Posted on 02 Apr 2024

Macrophages are important immune cells that play a crucial role in both the body's normal inflammatory response and also comprise a significant portion of solid tumors. Given that the density of macrophages within a tumor significantly influences its response to treatments, the capability to measure them noninvasively can offer a significant advantage in determining the most suitable therapeutic approach. Now, researchers are developing and clinically testing imaging technologies that can noninvasively examine and quantify these immune cells present in tumors.

The technology, called TAM-Sense, being tested at the University of California San Diego School of Medicine (La Jolla, CA, USA) works by feeding macrophages tiny drops of a dye that can be detected by magnetic resonance imaging (MRI). The TAM-Sense agent is a fluid composed of very tiny drops of a biologically inert fluorocarbon dye, integrates into the bloodstream upon injection. The macrophages detect and engulf these droplets, then collect at the inflammation sites, making it possible to visualize the dye inside them with a specifically modified MRI scanner. This process is similar to the routine MRI scan experience from a patient's perspective. The phase I clinical trial aims to explore TAM-Sense's effectiveness in individuals with recurrent head and neck tumors, marking its first clinical study.

TAM-Sense's potential extends beyond oncology, offering possible applications across various conditions characterized by significant inflammation, including autoimmune diseases, cardiovascular disorders, and infectious diseases. Given the tendency of macrophages to accumulate at pain sites within the body, this imaging technique promises to enhance the accuracy of pain management strategies by precisely locating these areas. Further, the researchers are planning to modify TAM-Sense for compatibility with positron emission tomography (PET) scanning, facilitating comprehensive body imaging. MRI scores over PET in providing high-resolution images over limited fields of view, while PET is superior in full-body scanning for disease detection. However, the PET approach will need further preclinical testing before it can be used on patients.

“Visualizing a patient’s inflammatory sites throughout the body will be invaluable for accurate clinical diagnosis and for planning precise therapeutic interventions,” said Eric Ahrens, Ph.D., a professor in the Department of Radiology at UC San Diego School of Medicine. “Current approaches using biopsies are invasive, and some tumors are inaccessible to biopsy. There is an urgent need for new, whole-body imaging technologies.”

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80 (33.855438232422): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

81 (251.05476379395): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 3477.0965576172): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

96 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

97 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

99 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

100 (315.90461730957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

101 (281.81076049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800739 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

102 (476.12190246582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

103 (332.11708068848): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

104 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

105 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

106 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

107 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

108 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

109 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

110 (174.99923706055): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

111 (!!!!! 94305.038452148): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

112 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

113 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

114 (615.83518981934): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800745 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800745 AND type='deeppockets_item' AND published='1' LIMIT 1

115 (!!!!! 1029124.0215302): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

116 (256.06155395508): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

117 (322.81875610352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

118 (257.01522827148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

119 (416.04042053223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

120 (250.81634521484): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

121 (277.04238891602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

122 (233.17337036133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

123 (789.88075256348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

124 (!!!!! 1796.9608306885): SELECT name FROM jos_deeppockets WHERE id=215

125 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=215

126 (449.89585876465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

127 (513.07678222656): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

128 (540.97175598145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

129 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

130 (!!!!! 23401.975631714): TRUNCATE TABLE jos_trademed_module

131 (838.04130554199): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

132 (!!!!! 1688.0035400391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (403.16581726074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

135 (!!!!! 1441.0018920898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

136 (!!!!! 3296.1368560791): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

137 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

138 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

139 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800745 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800745 AND type='deeppockets_item' AND published='1' LIMIT 1

140 (34.809112548828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

141 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

142 (234.12704467773): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

143 (!!!!! 3240.8237457275): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

144 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800745 AND published='1' LIMIT 1

145 (252.96211242676): select jos_twitters.link from jos_twitters where cat=10

146 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

147 (84.161758422852): select jos_google_plus.link from jos_google_plus where cat=10

148 (74.148178100586): select jos_linkedin.link from jos_linkedin where cat=10

149 (596.04644775391): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

150 (!!!!! 1580.9535980225): insert into jos_banners_delta values (14615,'2025-04-29 20:27:47','18.189.13.48','view'),(14202,'2025-04-29 20:27:47','18.189.13.48','view'),(14203,'2025-04-29 20:27:47','18.189.13.48','view')

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