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Next Generation MR-Guided Focused Ultrasound Ushers In Future of Incisionless Neurosurgery

By MedImaging International staff writers
Posted on 18 Apr 2024

Essential tremor, often called familial, idiopathic, or benign tremor, leads to uncontrollable shaking that significantly affects a person’s life. When traditional medications do not alleviate symptoms, surgery may become necessary. An alternative treatment option is focused ultrasound, which controls tremors without the need for surgical incisions and typically involves fewer complications. This procedure involves the use of MRI to accurately direct sound waves to a precise location in the brain believed to cause the tremors. Initially, low energy is used to ensure the patient can communicate any sensations or side effects they experience, allowing the physician to make personalized adjustments. Subsequently, the energy is gradually increased to create a small therapeutic lesion, resulting in many patients seeing immediate tremor improvement in the treated hand.

Insightec (Haifa, Israel;) has now launched Exablate Prime, the next generation of its MR-guided focused ultrasound, with improved functionality and safety features to facilitate incisionless neurosurgery. This system, a significant enhancement to the company’s Exablate Neuro platform, builds on more than a decade of research and development for enhancing the precision, efficiency, and overall experience for both the surgeon and patient. Similar to its predecessor, the Exablate Prime facilitates incisionless neurosurgery that can be performed as an outpatient procedure, offering relief for conditions like essential tremor and Parkinson’s disease. Notable improvements to the new Exablate Prime include an enriched user interface and enhancements to optimize productivity.

The new Exablate Prime comes with guided workflows, automated steps, and a streamlined UI. It features intelligent algorithms for one-click skull-density-ratio (SDR) calculations, automatic fusion and AC/PC identification, and efficient no-pass region detection. It enables intuitive and informative therapy delivery with temperature-driven control enabled by an accurate temperature prediction algorithm. Exablate Prime offers precise targeting and lesion shaping with sub-millimetric targeting control and advanced shaping masks. Other enhancements include improved cyber security, PACS connectivity, remote planning, and troubleshooting, automatic MR scan acquisition, intelligent targeting tools, and larger MR data sets in one planning session. The system also boasts an optional, upgraded 3T head coil for improved imaging and 3D thermal spot visualization. Insightec has obtained CE approval for Exablate Prime.

"Our unwavering commitment to enhancing patient care through innovative technology led us to develop Exablate Prime," said Maurice R. Ferre, M.D., CEO and chairman of the board of Insightec. "Although Exablate Neuro has revolutionized the field of neurosurgery, Exablate Prime takes it to entirely new levels, pushing the boundaries of what is possible. We couldn't be more proud of the end result – Exablate Prime is the future of incisionless neurosurgery."

"With the growing number of European countries supporting focused ultrasound as viable treatment option for essential tremor, Exablate Prime is truly exciting," commented Giuseppe Carbone, vice president of Insightec Europe. "We are confident it will make even more of a positive impact to empower Europeans living with essential tremor and Parkinson's disease – as well as their physicians."

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78 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

93 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

94 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800919 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

95 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

96 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

97 (360.96572875977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800919 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (310.89782714844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800915 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

99 (550.0316619873): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (349.04479980469): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

101 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

102 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

103 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

104 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

105 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

106 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

107 (287.05596923828): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

108 (!!!!! 19638.776779175): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

109 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

110 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

111 (397.92060852051): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800919 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800919 AND type='deeppockets_item' AND published='1' LIMIT 1

112 (!!!!! 485589.9810791): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (183.10546875): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

114 (396.9669342041): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

115 (156.16416931152): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

116 (324.01084899902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

117 (117.77877807617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

118 (253.91578674316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

119 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

120 (375.98609924316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

121 (226.02081298828): SELECT name FROM jos_deeppockets WHERE id=214

122 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=214

123 (560.99891662598): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (587.94021606445): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

125 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

126 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

127 (!!!!! 10609.149932861): TRUNCATE TABLE jos_trademed_module

128 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800919 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

129 (!!!!! 1224.0409851074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

131 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

132 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

133 (!!!!! 1493.9308166504): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

134 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

135 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

136 (126.83868408203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800919 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800919 AND type='deeppockets_item' AND published='1' LIMIT 1

137 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

138 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

139 (44.107437133789): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

140 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

141 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800919 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800919 AND published='1' LIMIT 1

142 (133.03756713867): select jos_twitters.link from jos_twitters where cat=10

143 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

144 (60.081481933594): select jos_google_plus.link from jos_google_plus where cat=10

145 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

146 (358.81996154785): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

147 (!!!!! 1441.9555664062): insert into jos_banners_delta values (14615,'2025-04-29 15:59:24','18.191.212.175','view'),(14202,'2025-04-29 15:59:24','18.191.212.175','view'),(14203,'2025-04-29 15:59:24','18.191.212.175','view')

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