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Wearable Ultrasound Sticker Helps Identify Early Signs of Acute Liver Failure

By MedImaging International staff writers
Posted on 12 Feb 2024

Human body tissues and organs naturally stiffen with age, and this process can be more pronounced in certain diseases, indicating a potential decline in health. Clinicians currently use ultrasound elastography to measure organ stiffness. This technique, akin to ultrasound imaging, involves a technician using a handheld probe over the skin to send sound waves into the body. These waves cause slight vibrations in internal organs, generating returning waves. The probe detects these vibrations, and their pattern is translated into a measure of the organ's stiffness. Ultrasound elastography is mainly utilized in intensive care units to monitor post-transplant patients, allowing technicians to check the new organ for signs of stiffening, acute failure, or rejection. However, continuous long-term monitoring isn’t feasible with this method, creating a risk of missing critical changes. Now, an ultrasound sticker previously developed to image deep tissues and organs could offer a more continuous, wearable alternative.

Engineers at MIT (Cambridge, MA, USA) have developed a small ultrasound sticker, roughly the size of a postage stamp, capable of monitoring deep internal organ stiffness. When worn on the skin, this sticker can detect signs of diseases like liver and kidney failure or the progression of solid tumors. The sticker emits sound waves that penetrate the skin and reflect off internal organs, with the returning wave patterns indicating organ rigidity. The team has successfully demonstrated that the sticker can continuously monitor organ stiffness for up to 48 hours, detecting subtle changes indicative of disease progression. In early experiments, the sensor identified signs of acute liver failure in rats.

Currently, the engineers are modifying the sticker’s design for human application. They are collaborating with clinicians to adapt the sticker for use in ICU patients recovering from organ transplants. The design is expected to remain largely unchanged for this application, with the sticker attaching to a patient's skin. Sound waves sent and received by the sticker can be processed by connected electronics, similar to EKG machines. The team also aims to develop a more portable, self-contained version of the sticker, incorporating all necessary electronics and processing into a larger patch. This advancement could enable patients to wear the sticker at home for extended periods, continuously monitoring conditions like the progression of solid tumors, which tend to harden as they worsen.

“When some organs undergo disease, they can stiffen over time,” said Xuanhe Zhao, professor of mechanical engineering at MIT. “With this wearable sticker, we can continuously monitor changes in rigidity over long periods of time, which is crucially important for early diagnosis of internal organ failure.”

“We believe this is a life-saving technology platform,” Zhao added. “In the future, we think that people can adhere a few stickers to their body to measure many vital signals, and image and track the health of major organs in the body.”

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81 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

93 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

94 (101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800226 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

95 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

96 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

97 (633.95500183105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800226 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (795.12596130371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (622.98774719238): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (203.84788513184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

101 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

102 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

103 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

104 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

105 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

106 (506.87789916992): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 26988.02947998): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (155.92575073242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

109 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

110 (715.01731872559): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800226 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800226 AND type='deeppockets_item' AND published='1' LIMIT 1

111 (!!!!! 533342.83828735): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (161.88621520996): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (575.06561279297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (71.048736572266): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

115 (385.04600524902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

117 (301.83792114258): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

119 (519.0372467041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (191.92695617676): SELECT name FROM jos_deeppockets WHERE id=214

121 (48.160552978516): SELECT name FROM jos_deeppockets WHERE id=214

122 (639.91546630859): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (579.1187286377): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

125 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

126 (!!!!! 11533.975601196): TRUNCATE TABLE jos_trademed_module

127 (164.03198242188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800226 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (669.00253295898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

131 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

132 (!!!!! 1598.1197357178): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

134 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

135 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800226 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800226 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (46.014785766602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

137 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

138 (51.975250244141): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

140 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800226 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800226 AND published='1' LIMIT 1

141 (179.05235290527): select jos_twitters.link from jos_twitters where cat=10

142 (53.882598876953): select jos_facebook.link from jos_facebook where cat=10

143 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

144 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

145 (447.98851013184): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 1639.1277313232): insert into jos_banners_delta values (14615,'2025-04-29 16:34:07','3.16.42.17','view'),(14202,'2025-04-29 16:34:07','3.16.42.17','view'),(14203,'2025-04-29 16:34:07','3.16.42.17','view')

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