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Wearable Ultrasound Non-Invasively Treats Chronic Limb-Threatening Ischemia

By MedImaging International staff writers
Posted on 01 Jan 2024

Peripheral arterial disease (PAD) is a condition affecting millions globally, where peripheral arteries become narrowed, restricting blood flow from the heart to other body parts. PAD patients with extreme blockages can progress to Chronic Limb-Threatening Ischemia (CLTI), experiencing severe pain, non-healing sores, and wounds, often leading to limb amputation. Now, a novel, non-invasive, wearable therapeutic ultrasound device designed to treat CLTI and PAD can improve tissue perfusion, reduce symptoms, and save limbs.

Vibrato Medical (Newport Beach, CA, USA) is developing the first wearable therapeutic ultrasound device designed to promote vasodilation and vessel growth. Based on decades of therapeutic ultrasound research and the latest technological advancements, Vibrato’s technology is the first wearable therapeutic ultrasound device designed to promote vasodilation and vessel growth. Unlike endovascular and surgical revascularization, Vibrato’s technology can be applied without a single skin incision. Therapeutic ultrasound, the scientific basis of Vibrato’s approach, has been validated through animal and clinical studies that found it demonstrated vasodilation, collateral vessel growth, and angiogenesis.

Vibrato has now announced that data from an early feasibility study of non-invasive therapeutic ultrasound (TUS) to treat CLTI has successfully met its endpoint. The study evaluated patients with infrapopliteal PAD and measured changes in foot perfusion and oxygenation as well as therapy tolerance, compliance, and perception. Participants, categorized as having Rutherford class 3, 4, or 5 PAD, underwent 30-40 TUS treatment sessions over two months. Remarkably, each participant exhibited statistically significant improvements in perfusion post-treatment, demonstrating the potential of this device to revolutionize treatment for individuals suffering from severe PAD and CLTI.

“These early findings are promising for the future of non-invasive therapeutic options to treat chronic limb-threatening ischemia,” said Juliana Elstad, CEO at Vibrato. “We’re looking forward to building on these findings as we begin our next prospective multi-center randomized clinical trial.”

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66 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

67 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

68 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

69 (39.815902709961): SELECT fid FROM jos_deeppockets WHERE id=294799765 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799765 AND published='1' LIMIT 1

70 (38.862228393555): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

71 (288.96331787109): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (277.99606323242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (47.206878662109): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (79.870223999023): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (49.114227294922): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (53.882598876953): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (116.82510375977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

106 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

107 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (79.870223999023): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

110 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

111 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (729.08401489258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (591.03965759277): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (465.86990356445): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

116 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

117 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

118 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

120 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

121 (287.05596923828): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

122 (!!!!! 45780.897140503): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

123 (!!!!! 1065.9694671631): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

124 (329.01763916016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

125 (!!!!! 1004.9343109131): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799765 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799765 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 457010.03074646): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (79.870223999023): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

130 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

132 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

134 (483.03604125977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (319.00405883789): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (257.01522827148): SELECT name FROM jos_deeppockets WHERE id=214

137 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=214

138 (509.97734069824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (403.16581726074): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

141 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

142 (!!!!! 9135.9615325928): TRUNCATE TABLE jos_trademed_module

143 (127.07710266113): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (674.00932312012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

148 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

149 (!!!!! 1104.8316955566): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

150 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

151 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

152 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799765 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799765 AND type='deeppockets_item' AND published='1' LIMIT 1

153 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

154 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (61.988830566406): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

156 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

157 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799765 AND published='1' LIMIT 1

158 (58.174133300781): select jos_twitters.link from jos_twitters where cat=10

159 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

160 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

161 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

162 (355.95893859863): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

163 (!!!!! 2938.985824585): insert into jos_banners_delta values (14615,'2025-04-29 21:38:41','3.142.211.95','view'),(14202,'2025-04-29 21:38:41','3.142.211.95','view'),(14203,'2025-04-29 21:38:41','3.142.211.95','view')

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