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Ultrasound-Based 3D Printing Technology Could Enable Surgery without Cutting Open Patient

By MedImaging International staff writers
Posted on 12 Dec 2023

The utilization of 3D-printing tools is expanding rapidly. From developing medical device prototypes and flexible electronics to engineering tissues for wound healing, the applications are diverse. Traditional 3D printing methods often involve slow, point-by-point building of the object on a robust printing platform. Over the past several years, researchers have made advances with photo-sensitive inks that quickly solidify when exposed to light, enhancing printing speed and quality. However, this method is limited by the need for transparent inks and is less effective for biomedical applications due to light's limited tissue penetration.

Now, engineers at Duke University (Durham, NC, USA) and Harvard Medical School (Boston, MA, USA) have made a significant leap forward by developing a biocompatible ink that solidifies into various 3D structures upon exposure to ultrasound waves. This new technique termed deep-penetrating acoustic volumetric printing (DVAP), enables the creation of biomedical structures deep within tissues, suitable for applications such as bone healing or heart valve repair. DVAP utilizes a specialized "sono-ink," comprising hydrogels, microparticles, and molecules designed to react specifically to ultrasound waves. When this sono-ink is introduced into the target area, an ultrasound printing probe emits focused sound waves that solidify the ink into detailed structures. These structures can vary significantly, from bone-like hexagonal scaffolds to hydrogel bubbles for organ application. The sono-ink's composition is adaptable, allowing for varying durability, degradability, or even color in the final product.

The team demonstrated DVAP's potential through three proof-of-concept experiments. In the first test, they successfully sealed a section of a goat’s heart, simulating a procedure for treating nonvalvular atrial fibrillation, which typically requires invasive surgery. The sono-ink was delivered to a goat heart’s left atrial appendage using a catheter in a printing chamber. The ultrasound probe then emitted waves through 12 mm of tissue, solidifying the ink without harming adjacent tissues, resulting in a flexible material capable of enduring heart-like movements. In a second experiment, they explored DVAP's capability for tissue reconstruction and regeneration. They created a bone defect in a chicken leg and injected the sono-ink, solidifying it through layers of skin and muscle tissue. The formed material seamlessly integrated with the bone, showing no adverse effects on nearby tissues.

Lastly, the team demonstrated DVAP's potential in therapeutic drug delivery. They infused a common chemotherapy drug into the sono-ink and delivered it to liver tissue samples. The ultrasound probe then solidified the ink into hydrogels, which gradually released the chemotherapy, diffusing it into the liver tissue. This groundbreaking approach by Duke and Harvard researchers demonstrates DVAP's vast potential in biomedical applications, offering a less invasive and more versatile alternative to traditional treatment methods.

“Because we can print through tissue, it allows for a lot of potential applications in surgery and therapy that traditionally involve very invasive and disruptive methods,” said Junjie Yao, associate professor of biomedical engineering at Duke. “This work opens up an exciting new avenue in the 3D printing world, and we’re excited to explore the potential of this tool together.”

Related Links:
Duke University
Harvard Medical School

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58 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (510.93101501465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 1160.1448059082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

61 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

62 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

63 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

64 (90.122222900391): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (510.93101501465): SELECT fid FROM jos_deeppockets WHERE id=294799565 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799565 AND published='1' LIMIT 1

66 (43.869018554688): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

67 (41.007995605469): select jos_twitters.link from jos_twitters where cat=10

68 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

69 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

70 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

71 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294799565 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799565 AND published='1' LIMIT 1

72 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

73 (319.00405883789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (267.02880859375): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (38.862228393555): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (67.949295043945): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (61.988830566406): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (49.829483032227): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

108 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

109 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (43.153762817383): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

112 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

113 (!!!!! 2542.0188903809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (505.92422485352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799563 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (287.05596923828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799563 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (531.19659423828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (327.11029052734): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

120 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

121 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

122 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

123 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

124 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

125 (190.01960754395): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 20508.050918579): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

128 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

129 (418.90144348145): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799565 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799565 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 534809.82780457): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (82.015991210938): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

134 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

136 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

138 (394.10591125488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (223.87504577637): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=214

141 (28.848648071289): SELECT name FROM jos_deeppockets WHERE id=214

142 (496.86431884766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (378.84712219238): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

145 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

146 (!!!!! 8497.953414917): TRUNCATE TABLE jos_trademed_module

147 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799565 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (918.86520385742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

152 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

153 (!!!!! 1080.0361633301): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

155 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

156 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799565 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799565 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

158 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (33.855438232422): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (305.8910369873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

161 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799565 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799565 AND published='1' LIMIT 1

162 (38.14697265625): select jos_twitters.link from jos_twitters where cat=10

163 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

164 (38.862228393555): select jos_google_plus.link from jos_google_plus where cat=10

165 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

166 (330.20973205566): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

167 (!!!!! 1163.0058288574): insert into jos_banners_delta values (14615,'2025-04-29 21:19:27','18.218.161.96','view'),(14202,'2025-04-29 21:19:27','18.218.161.96','view'),(14203,'2025-04-29 21:19:27','18.218.161.96','view')

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