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Groundbreaking Needle-Free Ultrasound Technology to Revolutionize Vaccine Delivery

By MedImaging International staff writers
Posted on 08 Dec 2023

A significant number of adults and children harbor intense fears of needles, a problematic factor given the reliance of public health on vaccinations, typically administered through injections. In response to this challenge, a novel ultrasound-based technique offers a needle-free and painless solution for vaccine delivery, potentially enhancing immune responses without the discomfort of a jab.

Researchers at University of Oxford (Oxford, UK) are exploring this innovative approach to vaccine administration that eliminates the need for needles. This technique employs an acoustic phenomenon known as 'cavitation,' which involves the formation and rapid collapse of bubbles triggered by sound waves. The team is focusing on utilizing the intense mechanical energy bursts from these collapsing bubbles in three key ways: firstly, to clear pathways through the skin's outer dead cell layer, enabling vaccine molecules to penetrate; secondly, to actively propel the drug molecules through these newly created channels; and thirdly, to permeate the cell membranes, a crucial step for certain vaccine types that need to enter the cells to be effective.

Initial tests on living organisms showed that while the cavitation method delivered substantially fewer vaccine molecules compared to traditional injection methods (700 times less), it surprisingly elicited a stronger immune response. The researchers speculate this increased efficiency might be due to the ultrasonic method targeting the skin, which is rich in immune cells, as opposed to muscle tissue typically targeted by injections. This discovery suggests the potential for a more effective and economical vaccine delivery method, reducing costs and improving efficacy, all while minimizing the risk of side effects.

“In my opinion, the main potential side effect is universal to all physical techniques in medicine: If you apply too much energy to the body, you can damage tissue,” said Darcy Dunn-Lawless, a doctoral student at the University of Oxford’s Institute of Biomedical Engineering. “Exposure to excessive cavitation can cause mechanical damage to cells and structures. However, there is good evidence that such damage can be avoided by limiting exposure, so a key part of my research is to try and fully identify where this safety threshold lies for vaccine delivery.”

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67 (190.01960754395): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

68 (51.975250244141): select jos_twitters.link from jos_twitters where cat=10

69 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

70 (29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10

71 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

72 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294799535 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799535 AND published='1' LIMIT 1

73 (34.809112548828): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

74 (169.99244689941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (132.08389282227): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (29.802322387695): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

109 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

110 (52.213668823242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799535 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799535 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

113 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

114 (48.160552978516): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799535 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (349.99847412109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799535 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (602.00691223145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (416.99409484863): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (106.8115234375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

119 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

120 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

121 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

122 (!!!!! 6479.9785614014): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

123 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

124 (253.91578674316): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 45891.046524048): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (183.10546875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

127 (211.95411682129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

128 (521.18301391602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799535 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799535 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 453296.89979553): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (72.002410888672): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (54.836273193359): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (402.92739868164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (235.79597473145): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (154.01840209961): SELECT name FROM jos_deeppockets WHERE id=214

140 (44.107437133789): SELECT name FROM jos_deeppockets WHERE id=214

141 (501.15585327148): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (365.9725189209): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

144 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

145 (!!!!! 8266.9258117676): TRUNCATE TABLE jos_trademed_module

146 (86.069107055664): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799535 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799535 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (773.19145202637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

151 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

152 (!!!!! 1515.1500701904): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

154 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

155 (59.843063354492): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799535 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799535 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (39.100646972656): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

157 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

158 (36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

160 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799535 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799535 AND published='1' LIMIT 1

161 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

162 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

163 (38.862228393555): select jos_google_plus.link from jos_google_plus where cat=10

164 (38.14697265625): select jos_linkedin.link from jos_linkedin where cat=10

165 (295.16220092773): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1271.0094451904): insert into jos_banners_delta values (14615,'2025-04-29 22:01:38','3.16.164.14','view'),(14202,'2025-04-29 22:01:38','3.16.164.14','view'),(14203,'2025-04-29 22:01:38','3.16.164.14','view')

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