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AI X-Ray Tool Estimates Bone Mineral Density for Early Diagnosis of Osteoporosis

By MedImaging International staff writers
Posted on 13 Oct 2023

Osteoporosis is a common health issue that leads to low bone mineral density (BMD), making bones fragile and increasing the risk of fractures. Diagnosing this condition typically involves specialized and often costly tests like dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Because of these limitations, there's a need for more convenient and budget-friendly screening options. Recently, machine learning techniques that use X-ray images to estimate BMD have become more popular, but these often require extensive training data. Researchers have now come up with a machine learning method that offers a simpler way to screen for osteoporosis and other bone conditions early on.

Researchers at Nara Institute of Science and Technology (NAIST, Nara, Japan) have devised an innovative method that utilizes a type of machine learning known as the hierarchical learning framework. This method estimates BMD from standard X-ray images. The research team used original QCT scans from patients to create a virtual X-ray image of the bone area, aligning it precisely with actual patient X-rays. This data was then used in three distinct training phases to develop a final BMD estimation model. Initially, the model focused on breaking down X-ray images to create a virtual X-ray image of the bone area. In the final phase, the model was trained to recognize the relationship between these virtual X-ray images and BMD values.

This method was able to accurately estimate BMD using just a single X-ray image and demonstrated high effectiveness even with a couple of hundred datasets of CT and X-ray image pairs. The model not only provides the BMD value but also generates a virtual X-ray image that shows the distribution of bone density, making the results easier to understand. To assess its effectiveness compared to traditional methods like DXA and QCT, the researchers performed validation tests with real clinical data. The BMD values obtained through this new method showed a strong correlation with those derived from DXA and QCT, confirming its reliability.

Additional validation tests further demonstrated the robustness of this method. It produced consistent BMD estimates despite changes in patient positioning or different levels of image compression. The outcomes indicate that this new method has enormous potential for regular medical use. It offers a way to conveniently screen for osteoporosis and monitor treatment, enabling timely intervention and potentially improving the lives of those living with the condition.

"Osteoporosis is generally diagnosed at advanced stages once its symptoms become apparent. X-ray images can be valuable for opportunistic diagnosis, but efficiently extracting BMD information from these has been a significant challenge,” said Yoshito Otake from NAIST. “We hoped to solve this problem by using information derived from the computed tomography (CT) image in the training stage to develop a model for an accurate, efficient, and explainable BMD estimation solely from an X-ray image."

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65 (54.121017456055): select jos_twitters.link from jos_twitters where cat=10

66 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

67 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

68 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

69 (32.186508178711): SELECT fid FROM jos_deeppockets WHERE id=294798946 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294798946 AND published='1' LIMIT 1

70 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=211 ORDER BY `ordering`

71 (340.93856811523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (258.20732116699): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

106 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

107 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798946 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798946 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

110 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

111 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798946 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (545.97854614258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798946 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (585.07919311523): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (329.97131347656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

116 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

117 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

118 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

120 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

121 (285.14862060547): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

122 (!!!!! 18749.952316284): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

123 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

124 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

125 (461.10153198242): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798946 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798946 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 1110689.163208): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 531658.88786316): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (!!!!! 1341.8197631836): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (324.96452331543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

130 (!!!!! 1234.0545654297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (293.01643371582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

132 (832.08084106445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

134 (!!!!! 1517.0574188232): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (!!!!! 2285.0036621094): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 3022.9091644287): SELECT name FROM jos_deeppockets WHERE id=211

137 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=211

138 (531.91184997559): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (509.02366638184): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1238.1076812744): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

141 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

142 (!!!!! 10605.096817017): TRUNCATE TABLE jos_trademed_module

143 (627.99453735352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798946 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (473.0224609375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798946 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (384.80758666992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (141.14379882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

148 (173.09188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

149 (!!!!! 1145.1244354248): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

150 (380.03921508789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

151 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

152 (695.22857666016): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798946 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798946 AND type='deeppockets_item' AND published='1' LIMIT 1

153 (232.93495178223): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

154 (97.036361694336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

155 (149.01161193848): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

156 (315.90461730957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

157 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798946 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798946 AND published='1' LIMIT 1

158 (62.942504882812): select jos_twitters.link from jos_twitters where cat=10

159 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

160 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

161 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

162 (231.98127746582): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

163 (846.14753723145): insert into jos_banners_delta values (14615,'2025-04-29 21:35:52','3.145.109.97','view'),(14202,'2025-04-29 21:35:52','3.145.109.97','view'),(14203,'2025-04-29 21:35:52','3.145.109.97','view')

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