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Researchers Develop AI Algorithm to Predict Immunotherapy Response

By MedImaging International staff writers
Posted on 12 Sep 2018

A team of French researchers have designed an algorithm and developed it to analyze Computed Tomography (CT) scan images, establishing for the first time that artificial intelligence (AI) can process medical images to extract biological and clinical information. The researchers have created a so-called radiomic signature, which defines the level of lymphocyte infiltration of a tumor and provides a predictive score for the efficacy of immunotherapy in the patient.

In the near future, this could make it possible for physicians to use imaging to identify biological phenomena in a tumor located anywhere in the body without performing a biopsy.

Currently, there are no markers, which can accurately identify patients who will respond to anti-PD-1/PD-L1 immunotherapy in a situation where only 15 to 30% of patients do respond to such treatment. The more immunologically richer the tumor environment (presence of lymphocytes), the higher is the chances of immunotherapy being effective. Hence, the researchers tried to characterize this environment using imaging and correlate this with the patients’ clinical response. In their study, the radiomic signature was captured, developed and validated genomically, histologically and clinically in 500 patients with solid tumors (all sites) from four independent cohorts.

The researchers first used a machine learning-based approach to teach the algorithm how to use relevant information extracted from CT scans of patients participating in an earlier study, which also held tumor genome data. Thus, based solely on images, the algorithm learned to predict what the genome might have revealed about the tumor immune infiltrate, in particular with respect to the presence of cytotoxic T-lymphocytes (CD8) in the tumor, thus establishing a radiomic signature.

The researchers tested and validated this signature in other cohorts, including that of TCGA (The Cancer Genome Atlas), thus demonstrating that imaging could predict a biological phenomenon, providing an estimation of the degree of immune infiltration of a tumor. Further, in order to test the signature’s applicability in a real situation and correlate it to the efficacy of immunotherapy, it was evaluated using CT scans performed before the start of treatment in patients participating in five phase I trials of anti-PD-1/PD-L1 immunotherapy. The researchers found that the patients in whom immunotherapy was effective at three and six months had higher radiomic scores as did those with better overall survival.

In their next clinical study, the researchers will assess the signature both retrospectively and prospectively, using a larger number of patients and stratifying them based on cancer type in order to refine the signature. They will also use more sophisticated automatic learning and AI algorithms to predict patient response to immunotherapy, while integrating data from imaging, molecular biology and tissue analysis. The researchers aim to identify those patients who are most likely to respond to treatment, thereby improving the efficacy/cost ratio of treatment.

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67 (!!!!! 2288.1031036377): select jos_facebook.link from jos_facebook where cat=10

68 (!!!!! 4092.9317474365): select jos_google_plus.link from jos_google_plus where cat=10

69 (536.91864013672): select jos_linkedin.link from jos_linkedin where cat=10

70 (93.221664428711): SELECT fid FROM jos_deeppockets WHERE id=294774855 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774855 AND published='1' LIMIT 1

71 (43.153762817383): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

72 (422.95455932617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (!!!!! 2860.0692749023): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (701.904296875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (202.89421081543): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (434.87548828125): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (285.86387634277): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (459.90943908691): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (680.92346191406): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (!!!!! 1919.0311431885): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (!!!!! 3938.9133453369): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (221.96769714355): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (253.91578674316): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (360.96572875977): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (144.00482177734): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (119.92454528809): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (101.08947753906): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (!!!!! 1815.7958984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

107 (135.89859008789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

108 (108.00361633301): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774855 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774855 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (925.06408691406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

111 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

112 (439.88227844238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774855 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (422.00088500977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774855 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (510.93101501465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (816.10679626465): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (559.09156799316): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

119 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

120 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

122 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

123 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

124 (385.04600524902): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 175252.19917297): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (330.20973205566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

127 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

128 (!!!!! 11554.002761841): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774855 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774855 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 1887490.9877777): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (!!!!! 8467.9126739502): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (!!!!! 3501.8920898438): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (419.85511779785): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (!!!!! 7508.0394744873): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (518.798828125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (53.882598876953): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (!!!!! 4613.1610870361): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (!!!!! 1430.9883117676): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (!!!!! 1157.0453643799): SELECT name FROM jos_deeppockets WHERE id=216

140 (375.98609924316): SELECT name FROM jos_deeppockets WHERE id=216

141 (!!!!! 6227.0164489746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (!!!!! 2983.8085174561): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (!!!!! 1285.0761413574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

144 (903.84483337402): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

145 (!!!!! 60512.781143188): TRUNCATE TABLE jos_trademed_module

146 (!!!!! 1713.0374908447): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774855 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (665.90309143066): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774855 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (!!!!! 1014.9478912354): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (!!!!! 1219.9878692627): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

151 (!!!!! 6236.0763549805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

152 (!!!!! 2038.0020141602): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (!!!!! 3874.0634918213): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

154 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

155 (524.04403686523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774855 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774855 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (879.04930114746): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

157 (!!!!! 1824.1405487061): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

158 (580.0724029541): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (503.0632019043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

160 (163.79356384277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774855 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774855 AND published='1' LIMIT 1

161 (!!!!! 1071.9299316406): select jos_twitters.link from jos_twitters where cat=10

162 (47.206878662109): select jos_facebook.link from jos_facebook where cat=10

163 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

164 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

165 (361.20414733887): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1114.1300201416): insert into jos_banners_delta values (14615,'2025-04-29 21:00:19','18.222.218.204','view'),(14202,'2025-04-29 21:00:19','18.222.218.204','view'),(14203,'2025-04-29 21:00:19','18.222.218.204','view')

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