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Study Shows How Deep Learning and AI Diagnose TB

By MedImaging International staff writers
Posted on 24 Apr 2017

Image: A chest X-Ray of a patient with active TB, and an X-Ray with a heat map overlay showing some of the results of the AI analysis (Photo courtesy of RSNA).

Researchers have found that they can use an artificial intelligence technique called deep learning to identify cases of tuberculosis on chest X-Ray exams with a net accuracy rate of 96%.

According to the World Health Organization (WHO) around 1.8 million people died from tuberculosis (TB) in 2016. A simple chest X-Ray exam can help radiologists identify the disease, but many TB patients live in remote areas without access to expert radiologists who can interpret the images, and diagnose the disease.

The study was carried out by researchers at the Thomas Jefferson University Hospital who trained artificial intelligence models to identify TB on chest X-rays. The goal of the research was to help screen and evaluate patients in TB-prevalent areas lacking access to radiologists. The study was published in the April 25, 2017, online issue of the journal Radiology.

The researchers used 1,007 X-Ray exams of patients with and without active TB for the study. The multiple TB-positive and TB-negative X-Ray datasets were used to train two different Deep Convolutional Neural Network (DCNN) models called AlexNet and GoogLeNet. The researchers found that the best performing Artificial Intelligence (AI) model was when both AlexNet and GoogLeNet were used together, resulting in a net accuracy of 96%.

Co-author of the study, Paras Lakhani, MD at TJUH, said, “There is a tremendous interest in artificial intelligence, both inside and outside the field of medicine. An artificial intelligence solution that could interpret radiographs for presence of TB in a cost-effective way could expand the reach of early identification and treatment in developing nations. The relatively high accuracy of the deep learning models is exciting. The applicability for TB is important because it’s a condition for which we have treatment options. It’s a problem that can be solved. We hope to prospectively apply this in a real world environment. An artificial intelligence solution using chest imaging can play a big role in tackling TB.”

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70 (254.86946105957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (211.00044250488): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (37.908554077148): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1029.0145874023): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (39.815902709961): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.133392333984): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (30.994415283203): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1183.9866638184): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

105 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

106 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768964 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (42.200088500977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768964 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (626.0871887207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

109 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

110 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294768964 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (574.82719421387): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294768964 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (552.89268493652): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (338.07754516602): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

115 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

116 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

117 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

118 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

119 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

120 (170.94612121582): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 85844.993591309): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (260.82992553711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

123 (185.01281738281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

124 (!!!!! 7132.7686309814): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768964 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768964 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1579919.0998077): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1548728.9428711): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 5768.0606842041): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (!!!!! 6003.8566589355): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (!!!!! 7762.9089355469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (!!!!! 7997.989654541): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (!!!!! 7744.0738677979): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (!!!!! 7979.8698425293): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 1218.0805206299): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (493.04962158203): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (498.05641174316): SELECT name FROM jos_deeppockets WHERE id=216

136 (181.19812011719): SELECT name FROM jos_deeppockets WHERE id=216

137 (705.00373840332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (784.15870666504): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 7817.9836273193): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

140 (381.9465637207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

141 (!!!!! 9776.1154174805): TRUNCATE TABLE jos_trademed_module

142 (721.93145751953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768964 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (620.84197998047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768964 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (525.95138549805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

147 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

148 (!!!!! 1595.0202941895): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

150 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

151 (555.03845214844): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768964 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768964 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (87.02278137207): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

153 (52.928924560547): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

154 (62.942504882812): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

156 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768964 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768964 AND published='1' LIMIT 1

157 (!!!!! 1403.0933380127): select jos_twitters.link from jos_twitters where cat=10

158 (!!!!! 11003.971099854): select jos_facebook.link from jos_facebook where cat=10

159 (48.87580871582): select jos_google_plus.link from jos_google_plus where cat=10

160 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10

161 (273.9429473877): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 3822.0882415771): insert into jos_banners_delta values (14615,'2025-04-29 21:08:39','3.23.102.192','view'),(14202,'2025-04-29 21:08:39','3.23.102.192','view'),(14203,'2025-04-29 21:08:39','3.23.102.192','view')

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