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AI Model Predicts 5-Year Breast Cancer Risk from Mammograms

By MedImaging International staff writers
Posted on 27 Mar 2024

Approximately 13% of U.S. women, or one in every eight, are predicted to develop invasive breast cancer over their lifetime, with 1 in 39 women (3%) succumbing to the illness, according to the American Cancer Society. Mammography screening remains a vital tool for early breast cancer detection, offering the most effective treatment window. Regular mammogram appointments can significantly reduce breast cancer mortality risks. Nonetheless, the challenge remains in accurately predicting which individuals will contract breast cancer solely through screening methods. Mirai, an advanced deep learning algorithm, has been recognized for its ability to predict breast cancer risk, although its decision-making process remains largely unexplained, creating risks of overreliance and misdiagnoses by radiologists. Now, researchers have developed an innovative, interpretable artificial intelligence (AI) model capable of predicting the five-year risk of breast cancer based on the analysis of mammograms.

In the study, researchers at Duke University (Durham, NC, USA) conducted a comparative study utilizing their newly devised deep learning model, dubbed AsymMirai, against Mirai's one to five-year breast cancer risk assessments. AsymMirai inherits its deep learning "front end" from Mirai but incorporates an interpretable module called local bilateral dissimilarity, focusing on the tissue contrast between the left and right breasts. This study analyzed 210,067 mammograms from 81,824 patients from the EMory BrEast imaging Dataset (EMBED) spanning from January 2013 to December 2020, employing both the Mirai and AsymMirai algorithms.

The findings revealed that the simplified deep learning model, AsymMirai, nearly matched the performance of the state-of-the-art Mirai algorithm in predicting breast cancer risk from one to five years. Moreover, this study highlighted the significance of bilateral asymmetry as a vital clinical indicator, suggesting its potential as a novel imaging marker for assessing breast cancer risk. The transparency behind AsymMirai's decision-making process makes it an invaluable tool for radiologists, enhancing the accuracy of breast cancer diagnosis and risk prediction.

"We can, with surprisingly high accuracy, predict whether a woman will develop cancer in the next 1 to 5 years based solely on localized differences between her left and right breast tissue," said the study's lead author, Jon Donnelly, B.S., a Ph.D. student in the Department of Computer Science at Duke University. "This could have public impact because it could, in the not-too-distant future, affect how often women receive mammograms."

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88 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

92 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

93 (90.122222900391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800679 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

94 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

95 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

96 (509.02366638184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800679 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

97 (653.02848815918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (510.21575927734): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

99 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

100 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

101 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

102 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

103 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

104 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

105 (382.90023803711): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

106 (!!!!! 26196.002960205): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

107 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

108 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

109 (491.14227294922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800679 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800679 AND type='deeppockets_item' AND published='1' LIMIT 1

110 (!!!!! 666100.97885132): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (106.0962677002): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

112 (331.16340637207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

113 (64.13459777832): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

114 (235.08071899414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

115 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

116 (202.89421081543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

117 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

118 (364.06517028809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

119 (169.03877258301): SELECT name FROM jos_deeppockets WHERE id=211

120 (128.03077697754): SELECT name FROM jos_deeppockets WHERE id=211

121 (663.04206848145): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (607.96737670898): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))211((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

124 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

125 (!!!!! 7721.9009399414): TRUNCATE TABLE jos_trademed_module

126 (!!!!! 3437.0422363281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800679 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

127 (400.06637573242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

128 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

130 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

131 (!!!!! 1158.9527130127): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

132 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

133 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

134 (149.96528625488): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800679 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800679 AND type='deeppockets_item' AND published='1' LIMIT 1

135 (52.928924560547): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

136 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=211 or channel_id is null)

137 (96.797943115234): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

138 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

139 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800679 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800679 AND published='1' LIMIT 1

140 (172.85346984863): select jos_twitters.link from jos_twitters where cat=10

141 (46.014785766602): select jos_facebook.link from jos_facebook where cat=10

142 (53.167343139648): select jos_google_plus.link from jos_google_plus where cat=10

143 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

144 (352.85949707031): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

145 (!!!!! 7098.913192749): insert into jos_banners_delta values (14615,'2025-04-29 16:29:27','18.223.109.25','view'),(14202,'2025-04-29 16:29:27','18.223.109.25','view'),(14203,'2025-04-29 16:29:27','18.223.109.25','view')

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